Kim Moon Suk, Seo Kwang Su, Seong Ha Soo, Cho Sun Hang, Lee Hai Bang, Hong Keum Duck, Kim Sun Kyung, Khang Gilson
Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Korea.
Biomed Mater Eng. 2005;15(3):229-38.
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.
分别在过量乙酸酐存在的条件下，通过使对羧基苯氧基丙烷（CPP）和癸二酸（SA）反应，合成了由4个单元组成的CPP预聚物和由约10个单元组成的SA预聚物。通过熔融缩聚工艺，使CPP预聚物和SA预聚物的混合物共聚，得到聚酸酐聚（CPP-SA）共聚物。获得了平均分子量高达110,000 g/mol的共聚物。通过向SA均聚物中添加CPP均聚物链段，聚（CPP-SA）共聚物的结晶度降低。聚（CPP-SA）共聚物在10天内逐渐降解。根据聚（CPP-SA）共聚物分子量的变化，未观察到失重的显著差异。由聚（CPP-SA）制成的薄片中卡莫司汀（BCNU）的释放呈现持续释放模式，没有初始突释现象且药物释放延迟。
