Sarlund H, Pyörälä K, Penttilä I, Laakso M
Department of Medicine, Kuopio University Hospital, Finland.
Arterioscler Thromb. 1992 Jun;12(6):657-63. doi: 10.1161/01.atv.12.6.657.
Coronary heart disease risk factor levels were studied in 184 first-degree relatives (sisters and brothers) of non-insulin-dependent diabetic subjects (124 relatives with normoglycemia, 34 relatives with impaired glucose tolerance [IGT], and 26 relatives with non-insulin-dependent diabetes mellitus [NIDDM]) and in 215 relatives of nondiabetic subjects (194 relatives with normoglycemia and 21 relatives with IGT). Subjects with IGT exhibited the highest insulin responses to an oral glucose load. Systolic blood pressure was significantly higher; serum high density lipoprotein cholesterol level was significantly lower; and total, low density lipoprotein, and very low density lipoprotein triglyceride levels were higher in the relatives with a family history of diabetes who had IGT or NIDDM than in the normoglycemic relatives without a family history of diabetes. These abnormal changes were not seen in normoglycemic relatives or relatives with IGT who had no family history of NIDDM. Thus, in relatives of diabetics, abnormal glucose tolerance seems to induce changes in cardiovascular heart disease risk factor levels that are similar to those observed in NIDDM. Therefore, a family history of diabetes adds substantially to the risk for atherosclerosis, particularly in subjects with IGT.
对184名非胰岛素依赖型糖尿病患者的一级亲属（兄弟姐妹）（124名血糖正常的亲属、34名糖耐量受损[IGT]的亲属和26名非胰岛素依赖型糖尿病[NIDDM]的亲属）以及215名非糖尿病患者的亲属（194名血糖正常的亲属和21名IGT亲属）的冠心病危险因素水平进行了研究。IGT患者对口服葡萄糖负荷的胰岛素反应最高。有糖尿病家族史且患有IGT或NIDDM的亲属，其收缩压显著更高；血清高密度脂蛋白胆固醇水平显著更低；总甘油三酯、低密度脂蛋白和极低密度脂蛋白甘油三酯水平均高于无糖尿病家族史的血糖正常亲属。在无NIDDM家族史的血糖正常亲属或IGT亲属中未观察到这些异常变化。因此，在糖尿病患者的亲属中，异常糖耐量似乎会引发心血管疾病危险因素水平的变化，这些变化与NIDDM患者中观察到的变化相似。所以，糖尿病家族史会显著增加动脉粥样硬化的风险，尤其是在IGT患者中。
