• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The potential use of PPARalpha agonists as immunosuppressive agents.

作者信息

Cunard Robyn

机构信息

Research and Medicine Services, Division of Nephrology, San Diego, CA 92161, USA.

出版信息

Curr Opin Investig Drugs. 2005 May;6(5):467-72.

PMID:15912959
Abstract

Fibrates are peroxisome proliferator-activated receptor (PPAR)alpha ligands that have been used to treat hyperlipidemia and atherosclerosis for many years, and research has demonstrated that these agents have immunosuppressive effects. PPARalpha is expressed in multiple inflammatory cell types, and its ligands abrogate expression of inflammatory diseases. This review focuses on the use of fibrates in inflammatory disease models. It also describes proposed mechanisms of action of PPARalpha ligands and discusses the potential use of these medications as immunosuppressive agents.

摘要

相似文献

1
The potential use of PPARalpha agonists as immunosuppressive agents.
Curr Opin Investig Drugs. 2005 May;6(5):467-72.
2
Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.血管生物学中的过氧化物酶体增殖物激活受体——分子机制与临床意义
Vascul Pharmacol. 2006 Jul;45(1):19-28. doi: 10.1016/j.vph.2005.11.014. Epub 2006 Jun 16.
3
Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression.贝特类药物通过增强CCAAT/增强子结合蛋白β（C/EBPβ）的表达，在不依赖过氧化物酶体增殖物激活受体α（PPARα）的情况下上调淋巴细胞中的TRIB3。
Mol Immunol. 2007 Feb;44(6):1218-29. doi: 10.1016/j.molimm.2006.06.006. Epub 2006 Sep 1.
4
Therapeutical effects of PPAR agonists assessed by biomarker modulation.通过生物标志物调节评估过氧化物酶体增殖物激活受体激动剂的治疗效果。
Biomarkers. 2005 Nov;10 Suppl 1:S30-6. doi: 10.1080/13547500500216702.
5
[Fibrates and markers of inflammation].[纤维酸类药物与炎症标志物]
Pol Merkur Lekarski. 2007 Jan;22(127):58-61.
6
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.具有PPARα和PPARγ激动剂活性的新型手性贝特类药物的合成、生物学评价及分子模拟研究
J Med Chem. 2005 Aug 25;48(17):5509-19. doi: 10.1021/jm0502844.
7
PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.过氧化物酶体增殖物激活受体α激动剂可抑制巨噬细胞中骨桥蛋白的表达，并降低2型糖尿病患者的血浆水平。
Diabetes. 2007 Jun;56(6):1662-70. doi: 10.2337/db06-1177. Epub 2007 Mar 14.
8
Recent progress in research on peroxisome proliferator-activated receptor alpha-selective ligands.过氧化物酶体增殖物激活受体α选择性配体的研究进展
IDrugs. 2004 Aug;7(8):746-54.
9
Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease.贝特类药物及未来的过氧化物酶体增殖物激活受体α激动剂在心血管疾病治疗中的应用
Nat Clin Pract Cardiovasc Med. 2008 Sep;5(9):542-53. doi: 10.1038/ncpcardio1278. Epub 2008 Jul 15.
10
Differential antiatherogenic effects of PPARalpha versus PPARgamma agonists: should we be surprised?
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1763-4. doi: 10.1161/01.ATV.0000181034.54148.8d.

引用本文的文献

1
Master Autophagy Regulator Transcription Factor EB Regulates Cigarette Smoke-Induced Autophagy Impairment and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis.自噬主要调节因子转录因子EB调控香烟烟雾诱导的自噬损伤及慢性阻塞性肺疾病-肺气肿发病机制。
Antioxid Redox Signal. 2017 Jul 20;27(3):150-167. doi: 10.1089/ars.2016.6842. Epub 2017 Feb 1.
2
Oxidative stress and apoptosis in a pig model of brain death (BD) and living donation (LD).脑死亡（BD）和活体捐献（LD）猪模型中的氧化应激和细胞凋亡。
J Transl Med. 2013 Oct 2;11:244. doi: 10.1186/1479-5876-11-244.
3
Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells.
研究资源：比较核受体图谱：基础状态和活化状态的腹膜B-1和B-2细胞
Mol Endocrinol. 2011 Mar;25(3):529-45. doi: 10.1210/me.2010-0384. Epub 2011 Jan 27.
4
TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1.在糖尿病肾脏中，TRB3 受到内质网应激标志物 CHOP 的刺激，是足细胞 MCP-1 的抑制剂。
Am J Physiol Renal Physiol. 2010 Nov;299(5):F965-72. doi: 10.1152/ajprenal.00236.2010. Epub 2010 Jul 21.
5
Gemfibrozil, stretching arms beyond lipid lowering.吉非贝齐，降脂作用之外的手臂拉伸。
Immunopharmacol Immunotoxicol. 2009;31(3):339-51. doi: 10.1080/08923970902785253.
6
WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease.WY14643，一种过氧化物酶体增殖物激活受体α（PPARα）配体，可减轻抗肾小球基底膜病的表达。
Clin Exp Immunol. 2007 Nov;150(2):386-96. doi: 10.1111/j.1365-2249.2007.03505.x. Epub 2007 Sep 20.
7
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines.过氧化物酶体增殖物激活受体（PPARs）在人结肠癌标本及正常和癌细胞系中的细胞增殖和凋亡中的作用。
PPAR Res. 2007;2007:93416. doi: 10.1155/2007/93416.