Brunet Jean-François, Rouiller Eric, Wannier Thierry, Villemure Jean-Guy, Bloch Jocelyne
Department of Neurosurgery, Lausanne University Hospital, Bugnon 46, 1011 Lausanne, Switzerland.
Exp Neurol. 2005 Nov;196(1):195-8. doi: 10.1016/j.expneurol.2005.04.005.
If successful, autologous brain cell transplantation is an attractive approach to repair lesions and restore function of the central nervous system. We demonstrate that monkey adult brain cells obtained from cortical biopsy and kept in culture for 4 weeks exhibit neural progenitor characteristics. After reimplantation into a lesion area of the donor cerebral cortex, these cells can successfully survive and acquire neuronal characteristics over time. These results open new perspectives in the field of brain repair and may lead to future clinical applications.
如果成功，自体脑细胞移植是修复中枢神经系统损伤和恢复功能的一种有吸引力的方法。我们证明，从皮质活检获得并在培养中保存4周的成年猴脑细胞具有神经祖细胞特征。将这些细胞重新植入供体大脑皮质的损伤区域后，它们能够成功存活，并随着时间的推移获得神经元特征。这些结果为脑修复领域开辟了新的前景，并可能导致未来的临床应用。
