Sambandamurthy Vasan K, Jacobs William R
Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Microbes Infect. 2005 May;7(5-6):955-61. doi: 10.1016/j.micinf.2005.04.001.
The recent advances in genetic tools to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study of their role in the virulence and pathogenesis of tuberculosis. The safety and vaccine potential of a few of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed.
用于操纵结核分枝杆菌的基因工具的最新进展，已促成了特定突变体的构建，并对其在结核病的毒力和发病机制中的作用进行了研究。本文讨论了其中一些结核分枝杆菌突变体作为抗结核候选疫苗的安全性和疫苗潜力。
