FR207944, an antifungal antibiotic from Chaetomium sp. No. 217 II. Isolation and structure elucidation.

作者信息

Kobayashi Motoo, Yoshimura Seiji, Kinoshita Takayoshi, Hashimoto Michizane, Hashimoto Seiji, Takase Shigehiro, Fujie Akihiko, Hino Motohiro, Hori Yasuhiro

机构信息

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tokyo, Japan.

出版信息

Biosci Biotechnol Biochem. 2005 May;69(5):1029-32. doi: 10.1271/bbb.69.1029.

DOI:10.1271/bbb.69.1029

PMID:15914927

Abstract

We discovered FR207944 produced by Chaetomium sp. No. 217 in the course of screening for antifungal antibiotics from natural products. FR207944 is identical with fuscoatroside, described in the preceding paper as an anti-Aspergillus flavus agent. Determination of the relative stereochemistry of fuscoatroside was made formally by comparison with WF11605 (16-Oxo-FR207944). We confirmed the stereochemistry on the basis of single crystal X-ray analysis.

摘要