[δ-氨基-γ-酮戊酸脱水酶基因多态性与职业性无机铅暴露的剂量及效应指标]

[ALAD polymorphism and indicators of dose and effects of occupational exposure to inorganic lead].

作者信息

De Palma G, Scotti E, Mozzoni P, Alinovi R, Apostoli P, Neri G, Soleo L, Cassano F, Carta P, Murgia N, Muzi G, Muttil A

机构信息

Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università degli Studi di Parma, Italy.

出版信息

G Ital Med Lav Ergon. 2005 Jan-Mar;27 Suppl 1:39-42.

PMID:15915653

Abstract

The delta-aminolevulinate dehydrase (ALAD) genetic polymorphism was investigated along with biomarkers of lead exposure and effect on 333 male workers, occupationally exposed to lead, with blood lead levels (PbB) higher than 100 microg/l. ALAD genotype frequencies were distributed as expected among Caucasians. Workers bearing at least one ALAD-2 allele showed PbB values slightly higher than those from ALAD-1-1 subjects, who also exhibited higher urinary delta-aminolevulinic acid (ALAU) and blood zinc protoporphyrin (ZPP) levels. The plasmatic lead (PbP)/PbB ratio was similar in both groups. Exposure and effect biomarkers were significantly each other correlated among ALAD-1-1 subjects only, who showed also a significant inverse relationship between ALAD activity and ZPP values. Results confirm previous studies, supporting the hypothesis that ALAD polymorphism may interfere with toxico-kinetic and toxico-dynamic parameters of occupational exposure to Pb.

摘要

对333名职业性接触铅且血铅水平（PbB）高于100微克/升的男性工人，研究了δ-氨基乙酰丙酸脱水酶（ALAD）基因多态性以及铅暴露和效应的生物标志物。ALAD基因型频率在白种人中的分布符合预期。携带至少一个ALAD-2等位基因的工人的PbB值略高于ALAD-1-1受试者，后者的尿δ-氨基乙酰丙酸（ALAU）和血锌原卟啉（ZPP）水平也更高。两组的血浆铅（PbP）/PbB比值相似。仅在ALAD-1-1受试者中，暴露和效应生物标志物之间存在显著相关性，他们的ALAD活性与ZPP值之间也存在显著负相关。结果证实了先前的研究，支持ALAD多态性可能干扰职业性铅暴露的毒代动力学和毒效动力学参数这一假设。