Watts R G
Division of Pediatric Hematology-Oncology, University of Alabama, Birmingham.
Cancer. 1992 Jun 15;69(12):3012-4. doi: 10.1002/1097-0142(19920615)69:12<3012::aid-cncr2820691225>3.0.co;2-m.
Childhood neuroblastoma is a neural crest-derived tumor that presents most commonly during this period of life. In disseminated form, it is resistant to cure by chemotherapy. The tumor tends to recur in diverse locations after an initial clinical response. The parenchyma of the central nervous system (CNS) is a rare location for metastatic disease and typically represents terminal disease spread. Therefore, effective therapy for CNS metastasis of neuroblastoma has not been reported. The authors describe the case of a child who had a large parenchymal CNS metastasis at the time of initial recurrence of Stage IV neuroblastoma. Chemotherapy with ifosfamide and etoposide resulted in complete resolution of this lesion.
儿童神经母细胞瘤是一种起源于神经嵴的肿瘤，最常出现在儿童期。呈播散性时，它对化疗难以治愈。该肿瘤在初始临床缓解后往往会在不同部位复发。中枢神经系统（CNS）实质是转移性疾病的罕见部位，通常代表疾病的终末期扩散。因此，尚未有关于神经母细胞瘤中枢神经系统转移有效治疗方法的报道。作者描述了一名儿童病例，该儿童在IV期神经母细胞瘤初次复发时出现了较大的中枢神经系统实质转移瘤。采用异环磷酰胺和依托泊苷进行化疗后，该病灶完全消退。
