Kofuji Kyoko, Qian Chun-Jun, Murata Yoshifumi, Kawashima Susumu
Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan.
J Inorg Biochem. 2005 Jun;99(6):1329-34. doi: 10.1016/j.jinorgbio.2005.03.007.
Vanadium, which is an insulin-mimetic metal ion, was efficiently adsorbed on chitosan (CS). The adsorption of vanadium on CS was affected by the vanadium/CS ratio and the initial concentration of vanadium in preparative medium under constant pH condition. The vanadium-CS complex was able to control vanadium release. Moreover, a consistent control of vanadium release was achieved by incorporation of the vanadium-CS complex into a CS gel. After implantation of the CS gel retaining the vanadium-CS complex into diabetic mice, insulin-mimetic efficacy was confirmed by observation of a steady reduction in blood glucose levels. The sustained vanadium release also contributed to minimization of the side-effects. Thus, CS gel retaining the vanadium-CS complex appears promising as a vehicle for vanadium with long-term action and a low toxicity leading to its clinical use.
钒作为一种具有胰岛素模拟作用的金属离子，能有效地吸附在壳聚糖（CS）上。在恒定pH条件下，钒在CS上的吸附受钒/CS比例和制备介质中钒的初始浓度影响。钒-CS复合物能够控制钒的释放。此外，通过将钒-CS复合物掺入CS凝胶中，实现了对钒释放的持续控制。将保留钒-CS复合物的CS凝胶植入糖尿病小鼠后，通过观察血糖水平持续降低，证实了其胰岛素模拟功效。钒的持续释放也有助于将副作用降至最低。因此，保留钒-CS复合物的CS凝胶有望作为一种载体用于钒，具有长期作用且毒性低，可用于临床。
