López I, Gámez M, Varga Z
Department of Statistics and Applied Mathematics, University of Almería, Almería 04120, Spain.
Biosystems. 2005 Jul;81(1):65-75. doi: 10.1016/j.biosystems.2005.02.006. Epub 2005 Apr 8.
In this paper we shortly discuss the problem of the equilibrium in the well-known Fisher type selection-mutation model, also providing a formula for particular three-allele models. The considered continuous-time dynamics is a known extension of the classical model of natural selection given by Fisher. We also extend the existing investigation of the observability of Fisher's model to the case when another evolutionary factor, mutation is also present. Moreover, we prove a result of technical character, which makes it possible to apply the methodology of nonlinear systems with invariant manifold, to models of artificial selection. For an illustration, a class of three-allele systems is presented in which the controllability into equilibrium is guaranteed without any condition on the biological parameters.
在本文中,我们简要讨论了著名的费希尔型选择 - 突变模型中的平衡问题,并给出了特定三等位基因模型的一个公式。所考虑的连续时间动态是费希尔给出的经典自然选择模型的一种已知扩展。我们还将费希尔模型可观测性的现有研究扩展到了存在另一个进化因素——突变的情况。此外,我们证明了一个具有技术性质的结果,这使得将具有不变流形的非线性系统方法应用于人工选择模型成为可能。作为例证,给出了一类三等位基因系统,其中在对生物学参数没有任何条件的情况下保证了达到平衡的可控性。