Shin Seung-Heon, Heo Won-Wook
Department of Otolaryngology, School of Medicine, Daegu Catholic University Hospital, 3056-6 Daemyung 4 Dong, Nam-Gu, Daegu 705-718, South Korea.
Auris Nasus Larynx. 2005 Jun;32(2):139-43. doi: 10.1016/j.anl.2005.01.015. Epub 2005 Mar 23.
In nasal septal deviation, the deviated narrow side is more frequently combined with sinusitis due to the mechanical obstruction of ostiomeatal unit. The purpose of this study was to determine whether reduced airflow has a harmful effect on nasal inflammation and the development of rhinosinusitis. Twenty-three healthy New Zealand white rabbit were used. One side of the nostril was closed in 15 rabbits and 5 rabbits served as control. Rabbits were sacrificed at 4, 8 and 12 weeks. The anterior maxillary and septal mucosa were obtained for EM and LM study. Mucociliary clearance rate was measured using the India ink method. At 4 weeks, the opened side mucosa showed ciliary losses and ulcerations in the mucosa, but at 8 and 12 weeks, the closed side showed more severe ulceration and ciliary loss than open side. The mucociliary clearance rate was 12.3 mm/min in the control group, but the open side was 8.7 and 7.1 mm/min and the closed side was 4.7 and 6.4 mm/min at 4 and 8 weeks, respectively. Electron microscopy showed many abnormal cilia at 8 weeks in both sides. These observations suggest that inadequate airflow is an important causative factor of nasal and sinus infection, and that patients with septal deviation have a similar chance of developing sinusitis in either side.
在鼻中隔偏曲中，由于窦口鼻道复合体的机械性阻塞，偏曲狭窄侧更常合并鼻窦炎。本研究的目的是确定气流减少是否对鼻炎症和鼻窦炎的发展有有害影响。使用了23只健康的新西兰白兔。15只兔子的一侧鼻孔被封闭，5只兔子作为对照。在4周、8周和12周时处死兔子。获取上颌前部和鼻中隔黏膜用于电镜和光镜研究。使用印度墨汁法测量黏液纤毛清除率。在4周时，开放侧黏膜显示黏膜中的纤毛缺失和溃疡，但在8周和12周时，封闭侧显示出比开放侧更严重的溃疡和纤毛缺失。对照组的黏液纤毛清除率为12.3毫米/分钟，但在4周和8周时，开放侧分别为8.7和7.1毫米/分钟，封闭侧分别为4.7和6.4毫米/分钟。电镜显示在8周时两侧均有许多异常纤毛。这些观察结果表明气流不足是鼻和鼻窦感染的一个重要致病因素，并且鼻中隔偏曲患者两侧发生鼻窦炎的机会相似。
