Torres-Rosell Jordi, Machin Felix, Aragón Luis
Medical Research Council, Clinical Sciences Centre, Imperial College London, London, UK.
Cell Cycle. 2005 Jul;4(7):868-72. doi: 10.4161/cc.4.7.1825. Epub 2005 Jul 5.
As a baton in a relay race, intact genomes need to be smoothly passed onto daughter cells every cell generation. Cohesin and condensin are multiprotein complexes involved in chromosome segregation during mitosis, they perform the crucial function of organizing and compacting chromosomes into pairs to facilitate their equal distribution in anaphase. Both complexes share a core of similar origin, containing a heterodimer formed by members of the conserved chromosomal ATPase family named Smc. A third complex containing Smc proteins at its core, the Smc5-Smc6 complex, previously known to be involved in DNA repair has recently been shown to contribute to chromosome segregation during anaphase. Smc5-Smc6 plays a role in the disjunction of repetitive regions. Here, we present results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome.
作为接力赛中的接力棒，完整的基因组需要在每一代细胞中顺利传递给子细胞。黏连蛋白和凝聚蛋白是参与有丝分裂期间染色体分离的多蛋白复合物，它们执行着将染色体组织并压缩成配对的关键功能，以促进其在后期的均匀分配。这两种复合物都有一个起源相似的核心，包含一个由保守的染色体ATP酶家族成员形成的异二聚体，名为Smc。第三种以Smc蛋白为核心的复合物，即Smc5-Smc6复合物，以前已知参与DNA修复，最近已被证明在后期有助于染色体分离。Smc5-Smc6在重复区域的分离中发挥作用。在这里，我们展示的结果进一步支持了Smc5-Smc6在维持重复核糖体DNA（rDNA）位点完整性方面的重要性，rDNA位点是芽殖酵母基因组中最大的重复区域。
