Yoon Keejung, Gaiano Nicholas
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nat Neurosci. 2005 Jun;8(6):709-15. doi: 10.1038/nn1475.
The Notch pathway, although originally identified in fruit flies, is now among the most heavily studied in mammalian biology. In mice, loss-of-function and gain-of-function work has demonstrated that Notch signaling is essential both during development and in the adult in a multitude of tissues. Prominent among these is the CNS, where Notch has been implicated in processes ranging from neural stem cell regulation to learning and memory. Here we review the role of Notch in the mammalian CNS by focusing specifically on mutations generated in mice. These mutations have provided critical insight into Notch function in the CNS and have led to the identification of promising new directions that are likely to generate important discoveries in the future.
Notch信号通路虽然最初是在果蝇中发现的，但如今已成为哺乳动物生物学中研究最为深入的领域之一。在小鼠中，功能丧失和功能获得性研究表明，Notch信号在发育过程中和成年期的多种组织中都至关重要。其中最突出的是中枢神经系统（CNS），Notch参与了从神经干细胞调节到学习和记忆等一系列过程。在此，我们通过特别关注小鼠中产生的突变来综述Notch在哺乳动物中枢神经系统中的作用。这些突变提供了对Notch在中枢神经系统中功能的关键见解，并引领人们发现了一些有前景的新方向，未来很可能会由此产生重要的发现。
