“双底物”类似物对克氏锥虫甘油醛-3-磷酸脱氢酶的选择性抑制作用
Selective inhibition of Trypanosoma cruzi GAPDH by "bi-substrate" analogues.
作者信息
Ladame Sylvain, Fauré Régis, Denier Colette, Lakhdar-Ghazal Faouzi, Willson Michèle
机构信息
University Chemical Laboratory, University of Cambridge, Cambridge CB2 1EW, UK.
出版信息
Org Biomol Chem. 2005 Jun 7;3(11):2070-2. doi: 10.1039/b504703j. Epub 2005 May 9.
DOI:10.1039/b504703j
PMID:15917890
Abstract
A new series of "bi-substrate" analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.
摘要
已经合成了一系列新的“双底物”类似物作为甘油醛-3-磷酸脱氢酶的潜在抑制剂，并且已经鉴定出一种先导化合物，它以良好的亲和力和非常高（50倍）的特异性抑制克氏锥虫的该酶。
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