Hansen T K
Immunoendocrine Research Unit, Medical Department M, Aarhus University Hospital, Aarhus, Denmark.
Horm Metab Res. 2005 Apr;37 Suppl 1:95-8. doi: 10.1055/s-2005-861372.
The complement system has evolved over time as an effective part of the immune system, acting effectively in frontline combat against invading microorganisms. Unfortunately, any war might involve "collateral damage", and emerging data indicate that activation of the complement system may cause damage to innocent bystander cells and tissues in some situations. This may apply to complement activation and inflammation as it occurs following myocardial ischemia and reperfusion, which is know to aggravate the subsequent myocardial injury; and it has recently been proposed that complement activation may be an important factor in the development of diabetic renal complications. Mannose-binding lectin (MBL, also known as mannan-binding lectin) is a plasma protein that activates the complement cascade after binding to carbohydrate structures. Circulating MBL levels vary widely from person to person, which is mainly due to frequently occurring polymorphisms within the encoding gene on chromosome 10. One may speculate that these genetically determined differences in MBL levels and hence in complement activation may play a role in existing familial clustering in both cardiovascular disease and diabetes-related vascular complications. The present review will focus on the function of MBL and the complement system, and on recent data indicating an association between MBL status and diabetic micro- and macrovascular complications.
补体系统随着时间的推移已演变为免疫系统的一个有效组成部分,在抵御入侵微生物的一线战斗中发挥着有效作用。不幸的是,任何战争都可能涉及“附带损害”,新出现的数据表明,在某些情况下,补体系统的激活可能会对无辜的旁观者细胞和组织造成损害。这可能适用于心肌缺血和再灌注后发生的补体激活和炎症,已知这会加重随后的心肌损伤;最近有人提出,补体激活可能是糖尿病肾脏并发症发生发展的一个重要因素。甘露糖结合凝集素(MBL,也称为甘露聚糖结合凝集素)是一种血浆蛋白,在与碳水化合物结构结合后激活补体级联反应。循环中的MBL水平因人而异,这主要是由于10号染色体上编码基因内频繁出现多态性。人们可能推测,这些由基因决定的MBL水平差异以及由此导致的补体激活差异,可能在心血管疾病和糖尿病相关血管并发症的现有家族聚集现象中起作用。本综述将重点关注MBL和补体系统的功能,以及最近表明MBL状态与糖尿病微血管和大血管并发症之间存在关联的数据。