补体激活增强是南亚人不良心血管风险状况的一部分。
Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
作者信息
Siezenga M A, Chandie Shaw P K, van der Geest R N, Mollnes T E, Daha M R, Rabelink T J, Berger S P
机构信息
Leiden University Medical Center, Department of Nephrology, Leiden, the Netherlands.
出版信息
Clin Exp Immunol. 2009 Jul;157(1):98-103. doi: 10.1111/j.1365-2249.2009.03959.x.
South Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 and SC5b-9 - the soluble end product of complement activation - in a group of 200 South Asians were compared with an age- and sex-matched control group of native Caucasians. In addition, the association between complement levels and albuminuria, an indicator of renal damage and a cardiovascular risk marker, was assessed in the diabetic South Asian group. Compared with native Caucasians, South Asians had significantly higher levels of both serum C3 and plasma SC5b-9, even when only non-diabetic South Asians were considered. Diabetic South Asians had significantly higher C3 levels compared with non-diabetic South Asians. In diabetic South Asians, higher levels of SC5b-9 were associated with an increased prevalence of albuminuria (odds ratio 5.4, 95% confidence interval 1.8-15.8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
在西方社会的南亚移民中，糖尿病及随后的血管并发症负担较重。糖尿病血管并发症与血管炎症相关。我们推测补体激活增强与之有关。因此，将200名南亚人的补体C3和SC5b-9（补体激活的可溶性终产物）水平与年龄和性别匹配的本地高加索人对照组进行了比较。此外，在糖尿病南亚人群中评估了补体水平与蛋白尿（肾损伤指标和心血管风险标志物）之间的关联。与本地高加索人相比，即使仅考虑非糖尿病南亚人，南亚人的血清C3和血浆SC5b-9水平也显著更高。糖尿病南亚人的C3水平显著高于非糖尿病南亚人。在糖尿病南亚人中，较高的SC5b-9水平与蛋白尿患病率增加相关（优势比5.4，95%置信区间1.8-15.8）。这些结果表明，补体激活增强是南亚人不良心血管风险特征的一部分。
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