Lee Ju-Seog, Thorgeirsson Snorri S
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4262, USA.
Semin Liver Dis. 2005;25(2):125-32. doi: 10.1055/s-2005-871192.
The underlying molecular basis for the heterogeneity in human liver cancer, hepatocellular carcinoma (HCC), is largely unknown. As with most other human cancers, the heterogeneous nature of HCC has hampered both treatment and prognostic predictions. Global gene expression profiling of human cancers is a promising new technology for refining the diagnosis and prognosis of HCC as well as for identifying potential therapeutic targets. Improved molecular characterization of HCC from gene expression profiling studies will undoubtedly improve the prediction of treatment responses, improve the selection of treatments for specific molecular subtypes of HCC, and ultimately improve the clinical outcome of HCC patients. We review the recent advances in gene expression profiling of HCC and discuss the biological and clinical insights obtained from these studies.
人类肝癌，即肝细胞癌（HCC）异质性的潜在分子基础在很大程度上尚不清楚。与大多数其他人类癌症一样，HCC的异质性阻碍了治疗和预后预测。人类癌症的全基因表达谱分析是一项很有前景的新技术，可用于完善HCC的诊断和预后评估，以及识别潜在的治疗靶点。通过基因表达谱研究对HCC进行更好的分子特征描述，无疑将改善对治疗反应的预测，改进针对HCC特定分子亚型的治疗选择，并最终改善HCC患者的临床结局。我们综述了HCC基因表达谱分析的最新进展，并讨论了从这些研究中获得的生物学和临床见解。
