四唑和恶二唑衍生物的细胞毒性、抗肿瘤及抗分枝杆菌活性
Cytotoxicity, antitumoral and antimycobacterial activity of tetrazole and oxadiazole derivatives.
作者信息
De Souza A O, Pedrosa M T C, Alderete J B, Cruz A F, Prado M A F, Alves R B, Silva C L
机构信息
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, S.P., Brazil.
出版信息
Pharmazie. 2005 May;60(5):396-7.
In this study, the antimycobacterial activity of mono and di-substituted tetrazole and oxadiazole derivatives and their precursors was assayed on Mycobacterium tuberculosis H37Rv, and cytotoxicity was evaluated on J774 macrophages and on tumoral cell lines. Structure Activity Relationship (SAR) analysis was performed using Principal Component Analysis (PCA) to determine the relationship between these compounds and their biological activities.
在本研究中，测定了单取代和二取代四唑及恶二唑衍生物及其前体对结核分枝杆菌H37Rv的抗分枝杆菌活性，并评估了其对J774巨噬细胞和肿瘤细胞系的细胞毒性。使用主成分分析（PCA）进行构效关系（SAR）分析，以确定这些化合物与其生物活性之间的关系。
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