肿瘤坏死因子相关凋亡诱导配体受体4在人外周血淋巴细胞中的限制性表达。

Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.

作者信息

Hasegawa Hiroo, Yamada Yasuaki, Harasawa Hitomi, Tsuji Tomohiro, Murata Ken, Sugahara Kazuyuki, Tsuruda Kazuto, Masuda Masato, Takasu Nobuyuki, Kamihira Shimeru

机构信息

Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

出版信息

Cell Immunol. 2004 Sep-Oct;231(1-2):1-7. doi: 10.1016/j.cellimm.2004.11.001. Epub 2004 Dec 21.

DOI:10.1016/j.cellimm.2004.11.001

PMID:15919363

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor but not normal cells, thus providing therapeutic possibilities for human cancers. However, it is not fully clear how widespread TRAIL receptors are, or how TRAIL signaling is modulated in normal cells. We characterized cell surface expression of TRAIL receptors in normal healthy donor peripheral blood and report that each of the TRAIL receptors are characteristically expressed on restricted cell populations. TRAIL-R1 is distinctively expressed on B-lymphocytes, TRAIL-R2 on monocytes, TRAIL-R3 on neutrophils and most impressively, CD8+ lymphocytes and NKT lymphocytes but not CD4+ lymphocytes express TRAIL-R4.

摘要

肿瘤坏死因子相关凋亡诱导配体（TRAIL）可诱导肿瘤细胞而非正常细胞凋亡，因此为人类癌症提供了治疗可能性。然而，目前尚不完全清楚TRAIL受体的分布有多广泛，或者TRAIL信号在正常细胞中是如何被调节的。我们对正常健康供体外周血中TRAIL受体的细胞表面表达进行了表征，并报告称每个TRAIL受体都在特定的细胞群体上有特征性表达。TRAIL-R1在B淋巴细胞上有独特表达，TRAIL-R2在单核细胞上表达，TRAIL-R3在中性粒细胞上表达，最引人注目的是，CD8+淋巴细胞和自然杀伤T细胞（NKT细胞）表达TRAIL-R4，而CD4+淋巴细胞不表达。