Salim A S
University Department of Surgery, Medical City, Baghdad, Iraq.
Chemotherapy. 1992;38(2):127-34. doi: 10.1159/000238952.
The influence of scavengers of oxygen-derived free radicals on survival in colonic cancer was studied. Following curative surgery for carcinoma of the sigmoid colon at Dukes' stage C, 198 patients making an uneventful recovery from surgery were randomized to the control group or to receive allopurinol (50 mg orally 4 times a day) or dimethyl sulphoxide (DMSO, 500 mg orally 4 times a day). In 144 fully evaluable patients who were studied for 5 years, allopurinol and DMSO incurred a significant (p less than 0.01) survival advantage over the whole period of study. The similarity in efficacy between allopurinol and DMSO and the fact that the only action they share is scavenging oxyradicals, suggest that these radicals are implicated in the detrimental effects of malignancy and that removing them provides a survival advantage in patients bearing colonic carcinoma.
研究了氧衍生自由基清除剂对结肠癌患者生存率的影响。在乙状结肠癌根治性手术后处于Dukes C期的患者中，198例术后恢复顺利的患者被随机分为对照组，或接受别嘌醇（每日4次，每次口服50mg）或二甲基亚砜（DMSO，每日4次，每次口服500mg）。在144例接受了5年研究的可全面评估的患者中，在整个研究期间，别嘌醇和DMSO均具有显著的生存优势（p<0.01）。别嘌醇和DMSO疗效的相似性以及它们唯一的共同作用是清除氧自由基这一事实表明，这些自由基与恶性肿瘤的有害作用有关，清除它们能为结肠癌患者带来生存优势。
