Kiviniemi Vesa J, Haanpää Hannu, Kantola Juha-Heikki, Jauhiainen Jukka, Vainionpää Vilho, Alahuhta Seppo, Tervonen Osmo
Department of Diagnostic Radiology, Oula University Hospital, P.O. Box 50, OYS 90029, Finland.
Magn Reson Imaging. 2005 May;23(4):531-7. doi: 10.1016/j.mri.2005.02.009.
The blood oxygen level-dependent (BOLD) magnetic resonance signal of functional brain cortices is dominated by very low frequency (VLF) fluctuations in anesthetized child patients. The temporal synchrony of the BOLD signal is also higher in anesthetized children compared with awake adults. The origin of the synchronous fluctuations can be related to maturation, pathological status or the anesthesia used in the imaging. Two of the three confounding variables (maturation and pathology) were controlled in this study. The effect of midazolam (4+/-0.8 mg) sedation on the BOLD signal was assessed in 12 healthy adults (aged 24+/-1.5 years) at 1.5 T. The VLF fluctuation power and temporal synchrony of the BOLD signal increased significantly after the sedation in the auditory and visual cortices. The fast Fourier transformation power spectral baseline fit parameters of the BOLD signal were also found to change significantly after sedation. It is concluded that the VLF fluctuation and temporal synchrony of the BOLD signal become increased after sedation in functional brain regions.
在麻醉的儿童患者中，功能性脑皮质的血氧水平依赖（BOLD）磁共振信号由极低频（VLF）波动主导。与清醒成年人相比，麻醉儿童的BOLD信号的时间同步性也更高。同步波动的起源可能与成熟度、病理状态或成像时使用的麻醉有关。本研究控制了三个混杂变量中的两个（成熟度和病理状态）。在1.5T场强下，评估了咪达唑仑（4±0.8mg）镇静对12名健康成年人（年龄24±1.5岁）BOLD信号的影响。镇静后，听觉和视觉皮质中BOLD信号的VLF波动功率和时间同步性显著增加。还发现镇静后BOLD信号的快速傅里叶变换功率谱基线拟合参数也发生了显著变化。得出的结论是，在功能性脑区镇静后，BOLD信号的VLF波动和时间同步性增加。
