Zhao J
Mental Health Institute of Hunan Medical University, Changsha.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1992 Feb;25(1):9-12, 60.
Intravenous clomipramine (n = 105) and oral clomipramine (n = 64) were compared in a control study of 169 inpatients with major depression. The therapeutic effects were evaluated with four-degree scale and the rating scales of HDS and CGI. The results showed intravenous group has earlier response and better antidepressive effects than oral group within treatment period of 2 weeks. No significant differences between two groups were found in anticholinergic side-reaction. Clinical useful values of intravenous clomipramine were discussed.
在一项针对169名重度抑郁症住院患者的对照研究中，对静脉注射氯米帕明（n = 105）和口服氯米帕明（n = 64）进行了比较。采用四级量表以及汉密尔顿抑郁量表（HDS）和临床总体印象量表（CGI）对治疗效果进行评估。结果显示，在2周的治疗期内，静脉注射组比口服组起效更早且抗抑郁效果更好。两组在抗胆碱能副作用方面未发现显著差异。文中讨论了静脉注射氯米帕明的临床应用价值。
