Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patients.

作者信息

Kojima Kenichiro, Oda Kuniyoshi, Homma Hitoshi, Takahashi Kazushi, Kanda Yoshiko, Inokami Taketoshi, Uchida Shunya

机构信息

Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.

出版信息

Nephrol Dial Transplant. 2005 Sep;20(9):1932-5. doi: 10.1093/ndt/gfh912. Epub 2005 May 26.

DOI:10.1093/ndt/gfh912

PMID:15919688

Abstract

BACKGROUND

Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients.

METHODS

We enrolled seven patients who were on regular haemodialysis and had sustained eosinophilia. White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers.

RESULTS

Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. CD8-positive lymphocyte counts and serum IgE levels were unaltered. Crossover tests in two cases reproduced the higher eosinophilia within 4 weeks after returning to the original non-vitamin E-bonded dialyzer.