Nielsen Jannik Kruse, Djurhuus Christian Born, Gravholt Claus Højbjerg, Carus Andreas Christiansen, Granild-Jensen Jacob, Orskov Hans, Christiansen Jens Sandahl
Medical Department M (Endocrinology and Diabetes), Arhus Sygehus, Arhus University Hospital, DK-8000 Arhus C, Denmark.
Diabetes. 2005 Jun;54(6):1635-9. doi: 10.2337/diabetes.54.6.1635.
Continuous glucose monitoring (CGM) is being explored using several types of glucose sensors. Some are designed for subcutaneous adipose tissue. It is important to determine to which extent these glucose fluctuations in different tissues reflect changes taking place in the central nervous system, where glucose sensing is thought to occur. We studied the ability of subcutaneous adipose interstitial fluid measurements to parallel glucose propagations in blood, muscle, and central nervous system (CNS) during hyper- and hypoglycemia. A subcutaneous CGM system was applied in the CNS, subcutaneous adipose tissue, and skeletal muscle of nine Vietnamese potbellied pigs, and data were compared with frequent sampling in blood. Alterations in glucose levels were induced with intravenous glucose and insulin. During hyperglycemia, no difference was detected in delay between blood and interstitial glucose levels in subcutaneous adipose tissue (18.0 +/- 0.8 min), muscle (18.0 +/- 0.9 min), and CNS (20.3 +/- 1.2 min), respectively. During hypoglycemia, we found no time difference between interstitial parameters in the three tissues. However, the amplitude of glucose changes varied considerably, with a smaller magnitude of glucose change taking place in the brain. The timing of glucose excursions in subcutaneous adipose tissue and muscle reflect excursions in CNS. The reduced magnitude of glucose excursions in the brain suggests that different mechanisms of glucose transport are operative in CNS compared with subcutaneous adipose tissue and muscle.
目前正在使用多种类型的葡萄糖传感器探索连续血糖监测（CGM）。有些传感器是为皮下脂肪组织设计的。确定不同组织中的这些血糖波动在多大程度上反映了中枢神经系统中发生的变化非常重要，因为人们认为葡萄糖传感发生在中枢神经系统中。我们研究了在高血糖和低血糖期间，皮下脂肪组织间质液测量值与血液、肌肉和中枢神经系统（CNS）中葡萄糖传播情况的平行关系。在9只越南大肚猪的中枢神经系统、皮下脂肪组织和骨骼肌中应用了皮下CGM系统，并将数据与血液中的频繁采样数据进行了比较。通过静脉注射葡萄糖和胰岛素来诱导血糖水平的变化。在高血糖期间，皮下脂肪组织（18.0±0.8分钟）、肌肉（18.0±0.9分钟）和中枢神经系统（20.3±1.2分钟）中血液和间质葡萄糖水平之间的延迟未检测到差异。在低血糖期间，我们发现这三种组织的间质参数之间没有时间差异。然而，葡萄糖变化的幅度差异很大，大脑中的葡萄糖变化幅度较小。皮下脂肪组织和肌肉中葡萄糖波动的时间反映了中枢神经系统中的波动情况。大脑中葡萄糖波动幅度的降低表明，与皮下脂肪组织和肌肉相比，中枢神经系统中葡萄糖转运的机制不同。
