锯齿状蛋白1特异性Notch1-磷脂酰肌醇3激酶信号通路对人乳头瘤病毒16型E6和E7的互补作用涉及多效致癌功能，且不依赖于CBF1；Su(H)；Lag-1激活。
Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.
作者信息
Veeraraghavalu Karthikeyan, Subbaiah Vanitha K, Srivastava Sweta, Chakrabarti Oishee, Syal Ruchi, Krishna Sudhir
机构信息
National Centre for Biological Sciences, TIFR, UAS-GKVK Campus, Bangalore 560065, India.
出版信息
J Virol. 2005 Jun;79(12):7889-98. doi: 10.1128/JVI.79.12.7889-7898.2005.
Abstract
We have analyzed the induction and role of phosphatidylinositol 3-kinase (PI3K) by Notch signaling in human papillomavirus (HPV)-derived cancers. Jagged1, in contrast to Delta1, is preferentially upregulated in human cervical tumors. Jagged1 and not Delta1 expression sustained in vivo tumors by HPV16 oncogenes in HaCaT cells. Further, Jagged1 expression correlates with the rapid induction of PI3K-mediated epithelial-mesenchymal transition in both HaCaT cells and a human cervical tumor-derived cell line, suggestive of Delta1;Serrate/Jagged;Lag2 ligand-specific roles. Microarray analysis and dominant-negatives reveal that Notch-PI3K oncogenic functions can be independent of CBF1;Su(H);Lag-1 activation and instead relies on Deltex1, an alternative Notch effector.
摘要
我们分析了Notch信号通路在人乳头瘤病毒（HPV）相关癌症中对磷脂酰肌醇3激酶（PI3K）的诱导作用及其角色。与Delta1不同，Jagged1在人宫颈肿瘤中优先上调。在HaCaT细胞中，HPV16致癌基因可在体内肿瘤中维持Jagged1而非Delta1的表达。此外，Jagged1的表达与HaCaT细胞和一种人宫颈肿瘤来源细胞系中PI3K介导的上皮-间质转化的快速诱导相关，提示Delta1、锯齿状蛋白/Jagged1、Lag2配体具有特异性作用。微阵列分析和显性阴性实验表明，Notch-PI3K致癌功能可能独立于CBF1、Su(H)、Lag-1激活，而是依赖于另一种Notch效应分子Deltex1。
相似文献
1
Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.锯齿状蛋白1特异性Notch1-磷脂酰肌醇3激酶信号通路对人乳头瘤病毒16型E6和E7的互补作用涉及多效致癌功能，且不依赖于CBF1；Su(H)；Lag-1激活。
J Virol. 2005 Jun;79(12):7889-98. doi: 10.1128/JVI.79.12.7889-7898.2005.
2
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.乳头瘤病毒介导的肿瘤进展与JAGGED1和与Notch激活相关的躁狂边缘蛋白表达的相互变化有关。
J Virol. 2004 Aug;78(16):8687-700. doi: 10.1128/JVI.78.16.8687-8700.2004.
3
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.边缘糖基转移酶对Delta1和Jagged1诱导的Notch1蛋白水解有不同的调节作用。
Mol Biol Cell. 2005 Feb;16(2):927-42. doi: 10.1091/mbc.e04-07-0614. Epub 2004 Dec 1.
4
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.宫颈癌细胞中Notch1信号的特异性下调是持续HPV-E6/E7表达和恶性转化后期步骤所必需的。
Genes Dev. 2002 Sep 1;16(17):2252-63. doi: 10.1101/gad.988902.
5
Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway.活化的Notch1通过PI3K-PKB/Akt依赖性途径抑制p53诱导的细胞凋亡，并维持人乳头瘤病毒16型E6和E7癌基因所致的细胞转化。
J Virol. 2003 Jun;77(12):7106-12. doi: 10.1128/jvi.77.12.7106-7112.2003.
6
Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.Delta1/锯齿状蛋白1激活的Notch1信号通路对骨形态发生蛋白诱导的成骨细胞分化的关键调控
J Biol Chem. 2005 Apr 22;280(16):15842-8. doi: 10.1074/jbc.M412891200. Epub 2005 Feb 4.
7
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.Notch信号通路在C2C12成肌细胞分化过程中施加了两个不同的阻滞。
Development. 1999 Apr;126(8):1689-702. doi: 10.1242/dev.126.8.1689.
8
Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.有证据表明，Notch-1介导的激活蛋白-1抑制作用需要C启动子结合因子1结合。
J Biol Chem. 2004 Mar 26;279(13):12337-45. doi: 10.1074/jbc.M311510200. Epub 2003 Nov 26.
9
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.边缘区通过Notch1和Notch2对Jagged1和Delta1信号进行差异性调节。
Nat Cell Biol. 2000 Aug;2(8):515-20. doi: 10.1038/35019553.
10
HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation.人乳头瘤病毒16型E6和E7癌蛋白调节Notch-1表达并协同诱导细胞转化。
J Cell Physiol. 2003 Mar;194(3):356-62. doi: 10.1002/jcp.10217.
引用本文的文献
1
Molecular Insights into HPV-Driven Cervical Cancer: Oncoproteins, Immune Evasion, and Epigenetic Modifications.人乳头瘤病毒驱动的宫颈癌的分子见解：癌蛋白、免疫逃逸和表观遗传修饰
Microorganisms. 2025 Apr 27;13(5):1000. doi: 10.3390/microorganisms13051000.
2
HES1 in cancer: a key player in tumorigenesis and its prognostic significance.癌症中的HES1：肿瘤发生的关键因素及其预后意义
Mol Genet Genomics. 2025 May 20;300(1):49. doi: 10.1007/s00438-025-02259-1.
3
ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.ASPM 通过阻止 FBXW7 在肝癌细胞中的结合来稳定 NOTCH 胞内结构域 1 并促进肿瘤发生。
Mol Oncol. 2024 Mar;18(3):562-579. doi: 10.1002/1878-0261.13589. Epub 2024 Jan 26.
4
Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation.无核血小板中的非经典非基因组形态发生素信号转导：循环中促血栓形成功能的关键决定因素。
Cell Commun Signal. 2024 Jan 3;22(1):13. doi: 10.1186/s12964-023-01448-y.
5
Notch signaling, hypoxia, and cancer.Notch信号通路、缺氧与癌症。
Front Oncol. 2023 Jan 31;13:1078768. doi: 10.3389/fonc.2023.1078768. eCollection 2023.
6
miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention.miR-23b-3p、miR-124-3p 和 miR-218-5p 对调节宫颈癌进展的细胞过程是否具有协同或相加作用？需要关注的分子平衡。
Int J Mol Sci. 2022 Nov 4;23(21):13551. doi: 10.3390/ijms232113551.
7
PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival.头颈部鳞状细胞癌中的PIK3CA基因突变：系统评价及其与HPV状态和患者生存的相关性
Cancers (Basel). 2022 Mar 2;14(5):1286. doi: 10.3390/cancers14051286.
8
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies.Notch、Hedgehog和Wnt信号通路在肿瘤对抗癌治疗耐药性中的作用
Front Cell Dev Biol. 2021 Apr 22;9:650772. doi: 10.3389/fcell.2021.650772. eCollection 2021.
9
Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy.探讨黑素瘤发生中的主要信号级联反应：靶向皮肤癌治疗的合理途径。
Biosci Rep. 2018 Oct 2;38(5). doi: 10.1042/BSR20180511. Print 2018 Oct 31.
10
Jagged-1 induced molecular alterations in HPV associated invasive squamous cell and adenocarcinoma of the human uterine cervix.锯齿-1 在 HPV 相关的人子宫颈浸润性鳞状细胞癌和腺癌中诱导的分子改变。
Sci Rep. 2018 Jun 19;8(1):9359. doi: 10.1038/s41598-018-27699-1.
本文引用的文献
1
Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development.果蝇基因 Serrate 和 Delta 在翅膀发育过程中的异位表达揭示了其不同的功能。
Dev Genes Evol. 1996 Sep;206(2):91-101. doi: 10.1007/s004270050035.
2
A fluorescent orthotopic model of metastatic cervical carcinoma.转移性宫颈癌的荧光原位模型。
Clin Exp Metastasis. 2004;21(3):275-81. doi: 10.1023/b:clin.0000037729.75981.9e.
3
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.乳头瘤病毒介导的肿瘤进展与JAGGED1和与Notch激活相关的躁狂边缘蛋白表达的相互变化有关。
J Virol. 2004 Aug;78(16):8687-700. doi: 10.1128/JVI.78.16.8687-8700.2004.
4
Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw.Notch与发育及肿瘤进展中的上皮-间质转化：情况更糟了。
Cell Cycle. 2004 Jun;3(6):718-21. Epub 2004 Jun 28.
5
Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras.人乳头瘤病毒16型E6蛋白第83位氨基酸变体增强E6介导的丝裂原活化蛋白激酶信号传导，并通过Notch信号传导和致癌性Ras差异调节肿瘤发生。
J Virol. 2004 Jun;78(11):5934-45. doi: 10.1128/JVI.78.11.5934-5945.2004.
6
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.抗原呈递细胞上不同的Notch配体对不同CD4辅助性T细胞命运的指令作用。
Cell. 2004 May 14;117(4):515-26. doi: 10.1016/s0092-8674(04)00451-9.
7
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.细胞外信号调节激酶（ERK）的激活在上皮细胞层中传播，并在伤口愈合过程中调节其迁移。
Curr Biol. 2004 Apr 20;14(8):731-5. doi: 10.1016/j.cub.2004.03.060.
8
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition.转化生长因子-β/ Smad信号通路与Jagged1/Notch信号通路在上皮-间质转化中的整合
EMBO J. 2004 Mar 10;23(5):1155-65. doi: 10.1038/sj.emboj.7600069. Epub 2004 Feb 19.
9
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.Notch在心脏发育和致癌转化过程中促进上皮-间质转化。
Genes Dev. 2004 Jan 1;18(1):99-115. doi: 10.1101/gad.276304. Epub 2003 Dec 30.
10
Notch1 can contribute to viral-induced transformation of primary human keratinocytes.Notch1 可促进病毒诱导的原代人角质形成细胞的转化。
Cancer Res. 2003 Dec 15;63(24):8687-94.
Zotero 插件