Guo Mingzhou, Niu Yang, Xie Min, Liu Xiansheng, Li Xiaochen
Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Pulmonary Diseases of National Health Commission, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Front Oncol. 2023 Jan 31;13:1078768. doi: 10.3389/fonc.2023.1078768. eCollection 2023.
Notch signaling is involved in cell fate determination and deregulated in human solid tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis and cancer development. Recently, HIFs have been shown to trigger the Notch signaling pathway in a variety of organisms and tissues. In this review, we focus on the pro- and anti-tumorigenic functions of Notch signaling and discuss the crosstalk between Notch signaling and cellular hypoxic response in cancer pathogenesis, including epithelia-mesenchymal transition, angiogenesis, and the maintenance of cancer stem cells. The pharmacological strategies targeting Notch signaling and hypoxia in cancer are also discussed in this review.
Notch信号通路参与细胞命运的决定，且在人类实体瘤中失调。缺氧是许多实体瘤的一个重要特征，它激活缺氧诱导因子（HIFs）及其下游靶点，以促进肿瘤发生和癌症发展。最近，已表明HIFs在多种生物体和组织中触发Notch信号通路。在本综述中，我们聚焦于Notch信号通路的促肿瘤和抗肿瘤功能，并讨论在癌症发病机制中Notch信号通路与细胞缺氧反应之间的相互作用，包括上皮-间质转化、血管生成以及癌症干细胞的维持。本综述还讨论了针对癌症中Notch信号通路和缺氧的药理学策略。
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