卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）蛋白K-bZIP多聚化区域的研究：推测的亮氨酸拉链区域编码一个具有异常结构的多聚化结构域。
Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.
作者信息
Al Mehairi Salama, Cerasoli Eleanora, Sinclair Alison J
机构信息
School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.
出版信息
J Virol. 2005 Jun;79(12):7905-10. doi: 10.1128/JVI.79.12.7905-7910.2005.
Abstract
The K8 gene of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, K-bZIP (RAP, K8) and Zta (BZLF1, ZEBRA, Z) have both been proposed to be members of the bZIP family of transcription factors, forming multimers via a coiled-coil motif termed a leucine zipper. Substantial evidence supporting this model for Zta is published. Here, we demonstrate that the proposed leucine zipper region of K-bZIP (amino acids 182 to 218) is required for multimer formation but that it does not fold as a coiled coil.
摘要
卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）的K8基因与爱泼斯坦-巴尔病毒的BZLF1基因具有许多功能相似性。K8和BZLF1的蛋白产物，即K-bZIP（RAP、K8）和Zta（BZLF1、ZEBRA、Z），均被认为是bZIP转录因子家族的成员，它们通过一种称为亮氨酸拉链的卷曲螺旋基序形成多聚体。已有大量支持Zta这一模型的证据发表。在此，我们证明K-bZIP的假定亮氨酸拉链区域（氨基酸182至218）是多聚体形成所必需的，但它并不折叠成卷曲螺旋。
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