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1
Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）蛋白K-bZIP多聚化区域的研究：推测的亮氨酸拉链区域编码一个具有异常结构的多聚化结构域。
J Virol. 2005 Jun;79(12):7905-10. doi: 10.1128/JVI.79.12.7905-7910.2005.
2
bZIP proteins of human gammaherpesviruses.人类γ疱疹病毒的碱性亮氨酸拉链蛋白
J Gen Virol. 2003 Aug;84(Pt 8):1941-1949. doi: 10.1099/vir.0.19112-0.
3
K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation.卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型（KSHV/HHV-8）的K-bZIP与KSHV/HHV-8的Rta结合，并抑制Rta介导的反式激活。
J Virol. 2003 Mar;77(6):3809-15. doi: 10.1128/jvi.77.6.3809-3815.2003.
4
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）编码一种爱泼斯坦-巴尔病毒bZip蛋白EB1的同源物。
J Gen Virol. 1999 Mar;80 ( Pt 3):557-561. doi: 10.1099/0022-1317-80-3-557.
5
Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.卡波西肉瘤相关疱疹病毒K8蛋白与hSNF5相互作用。
J Gen Virol. 2003 Mar;84(Pt 3):665-676. doi: 10.1099/vir.0.18699-0.
6
Gene expression from the ORF50/K8 region of Kaposi's sarcoma-associated herpesvirus.卡波西肉瘤相关疱疹病毒ORF50/K8区域的基因表达。
Virology. 1999 Oct 25;263(2):436-49. doi: 10.1006/viro.1999.9963.
7
Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.卡波西肉瘤相关疱疹病毒编码一种与爱泼斯坦-巴尔病毒的BZLF1具有同源性的bZIP蛋白。
J Virol. 1999 Mar;73(3):1909-17. doi: 10.1128/JVI.73.3.1909-1917.1999.
8
Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression.卡波西肉瘤相关疱疹病毒K-bZIP是K-Rta的共调节因子：物理相互作用及启动子依赖性转录抑制
J Virol. 2003 Jan;77(2):1441-51. doi: 10.1128/jvi.77.2.1441-1451.2003.
9
The zipper region of Epstein-Barr virus bZIP transcription factor Zta is necessary but not sufficient to direct DNA binding.爱泼斯坦-巴尔病毒bZIP转录因子Zta的拉链区域是指导DNA结合所必需的，但并不充分。
J Virol. 2003 Jul;77(14):8173-7. doi: 10.1128/jvi.77.14.8173-8177.2003.
10
Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication.卡波西肉瘤相关疱疹病毒K-bZIP对K-Rta的转录抑制对于oriLyt依赖性DNA复制并非必需。
Virology. 2007 Dec 20;369(2):340-50. doi: 10.1016/j.virol.2007.08.019. Epub 2007 Sep 21.

引用本文的文献

1
Kaposi's Sarcoma-Associated Herpesvirus K8 Is an RNA Binding Protein That Regulates Viral DNA Replication in Coordination with a Noncoding RNA.卡波氏肉瘤相关疱疹病毒 K8 是一种 RNA 结合蛋白，它与非编码 RNA 协调调节病毒 DNA 复制。
J Virol. 2018 Mar 14;92(7). doi: 10.1128/JVI.02177-17. Print 2018 Apr 1.
2
Viral manipulation of the cellular sumoylation machinery.病毒对细胞 sumoylation 机制的操纵。
Cell Commun Signal. 2017 Jul 14;15(1):27. doi: 10.1186/s12964-017-0183-0.
3
Initiation of lytic DNA replication in Epstein-Barr virus: search for a common family mechanism.爱泼斯坦-巴尔病毒中裂解性DNA复制的起始：探寻共同的家族机制。
Future Virol. 2010 Jan;5(1):65-83. doi: 10.2217/fvl.09.69.
4
Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication.亮氨酸拉链结构域对于卡波西肉瘤相关疱疹病毒（KSHV）的 K-bZIP 蛋白与组蛋白去乙酰化酶相互作用是必需的，并且对于 KSHV 的复制也是重要的。
J Biol Chem. 2012 May 4;287(19):15622-34. doi: 10.1074/jbc.M111.315861. Epub 2012 Mar 13.
5
Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53.分析 Epstein Barr 病毒编码（EBV）BZLF-1（ZEBRA）蛋白中的锚蛋白样区域：对与 NF-κB 和 p53 相互作用的影响。
Virol J. 2011 Sep 5;8:422. doi: 10.1186/1743-422X-8-422.
6
Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication.卡波西肉瘤相关疱疹病毒K-bZIP对K-Rta的转录抑制对于oriLyt依赖性DNA复制并非必需。
Virology. 2007 Dec 20;369(2):340-50. doi: 10.1016/j.virol.2007.08.019. Epub 2007 Sep 21.
7
Atypical bZIP domain of viral transcription factor contributes to stability of dimer formation and transcriptional function.病毒转录因子的非典型bZIP结构域有助于二聚体形成的稳定性和转录功能。
J Virol. 2007 Jul;81(13):7149-55. doi: 10.1128/JVI.00215-07. Epub 2007 Apr 25.

本文引用的文献

1
Viruses and tumours--an update.病毒与肿瘤——最新进展
Eur J Cancer. 2004 Sep;40(13):1998-2005. doi: 10.1016/j.ejca.2003.11.039.
2
Biophysical and mutational analysis of the putative bZIP domain of Epstein-Barr virus EBNA 3C.爱泼斯坦-巴尔病毒EBNA 3C假定bZIP结构域的生物物理和突变分析
J Virol. 2004 Sep;78(17):9431-45. doi: 10.1128/JVI.78.17.9431-9445.2004.
3
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcription.卡波西肉瘤相关疱疹病毒ori-Lyt依赖性DNA复制：复制的顺式作用要求及与ori-Lyt相关的RNA转录
J Virol. 2004 Aug;78(16):8615-29. doi: 10.1128/JVI.78.16.8615-8629.2004.
4
Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.十四烷酰佛波醇乙酸酯诱导的AP1途径对卡波西肉瘤相关疱疹病毒RTA、RAP和MTA启动子的早期激活
J Virol. 2004 Apr;78(8):4248-67. doi: 10.1128/jvi.78.8.4248-4267.2004.
5
Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP).卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型DNA复制的裂解起始区的扩增依赖于一个顺式作用的富含AT的区域、一个ORF50反应元件以及反式作用因子ORF50（K-Rta）和K8（K-bZIP）。
Virology. 2004 Jan 20;318(2):542-55. doi: 10.1016/j.virol.2003.10.016.
6
bZIP proteins of human gammaherpesviruses.人类γ疱疹病毒的碱性亮氨酸拉链蛋白
J Gen Virol. 2003 Aug;84(Pt 8):1941-1949. doi: 10.1099/vir.0.19112-0.
7
The zipper region of Epstein-Barr virus bZIP transcription factor Zta is necessary but not sufficient to direct DNA binding.爱泼斯坦-巴尔病毒bZIP转录因子Zta的拉链区域是指导DNA结合所必需的，但并不充分。
J Virol. 2003 Jul;77(14):8173-7. doi: 10.1128/jvi.77.14.8173-8177.2003.
8
Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）的分子遗传学、流行病学及发病机制
Microbiol Mol Biol Rev. 2003 Jun;67(2):175-212, table of contents. doi: 10.1128/MMBR.67.2.175-212.2003.
9
Kaposi's sarcoma-associated herpesvirus lytic origin (ori-Lyt)-dependent DNA replication: identification of the ori-Lyt and association of K8 bZip protein with the origin.卡波西肉瘤相关疱疹病毒裂解性起始点（ori-Lyt）依赖性DNA复制：ori-Lyt的鉴定以及K8 bZip蛋白与该起始点的关联
J Virol. 2003 May;77(10):5578-88. doi: 10.1128/jvi.77.10.5578-5588.2003.
10
CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.CCAAT/增强子结合蛋白α与ZTA相互作用，并在爱泼斯坦-巴尔病毒裂解周期中介导ZTA诱导的p21（CIP-1）积累和G1期细胞周期阻滞。
J Virol. 2003 Jan;77(2):1481-500. doi: 10.1128/jvi.77.2.1481-1500.2003.

卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）蛋白K-bZIP多聚化区域的研究：推测的亮氨酸拉链区域编码一个具有异常结构的多聚化结构域。

Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.

作者信息

Al Mehairi Salama, Cerasoli Eleanora, Sinclair Alison J

机构信息

School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

出版信息

J Virol. 2005 Jun;79(12):7905-10. doi: 10.1128/JVI.79.12.7905-7910.2005.

DOI:10.1128/JVI.79.12.7905-7910.2005
PMID:15919946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1143620/
Abstract

The K8 gene of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, K-bZIP (RAP, K8) and Zta (BZLF1, ZEBRA, Z) have both been proposed to be members of the bZIP family of transcription factors, forming multimers via a coiled-coil motif termed a leucine zipper. Substantial evidence supporting this model for Zta is published. Here, we demonstrate that the proposed leucine zipper region of K-bZIP (amino acids 182 to 218) is required for multimer formation but that it does not fold as a coiled coil.

摘要

卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）的K8基因与爱泼斯坦-巴尔病毒的BZLF1基因具有许多功能相似性。K8和BZLF1的蛋白产物，即K-bZIP（RAP、K8）和Zta（BZLF1、ZEBRA、Z），均被认为是bZIP转录因子家族的成员，它们通过一种称为亮氨酸拉链的卷曲螺旋基序形成多聚体。已有大量支持Zta这一模型的证据发表。在此，我们证明K-bZIP的假定亮氨酸拉链区域（氨基酸182至218）是多聚体形成所必需的，但它并不折叠成卷曲螺旋。