Aguzzi F, Bergami M R, Gasparro C, Bellotti V, Merlini G
Central Laboratory, Hospital of Stradella, Pavia, Italy.
Eur J Haematol. 1992 Apr;48(4):192-5. doi: 10.1111/j.1600-0609.1992.tb01584.x.
We report on the occurrence of monoclonal components observed in a provincial hospital in northern Italy from 1987 to 1990. The monoclonal components were detected by visual inspection of high-resolution acetate serum electrophoreses and typed by immunofixation. The percentage of monoclonal components increases steeply with age, and reaches a plateau of 7-8% in individuals over 55 years old. Besides the high percentage of monoclonal component, the other relevant finding of this study is that approximately 80% of monoclonal components are of low concentration (less than 5 g/l). Most of these subjects with small monoclonal component passed undetected in the previous studies on the prognostic significance of monoclonal gammapathy. These findings indicate the need for a revision of the current concepts on the biological and clinical significance of MC discovered by chance.
我们报告了1987年至1990年期间在意大利北部一家省级医院观察到的单克隆成分的发生情况。通过对高分辨率醋酸纤维素血清电泳进行目视检查来检测单克隆成分，并通过免疫固定进行分型。单克隆成分的百分比随年龄急剧增加，在55岁以上的个体中达到7-8%的平台期。除了单克隆成分的高比例外，本研究的另一个相关发现是，大约80%的单克隆成分浓度较低（低于5 g/l）。在先前关于单克隆丙种球蛋白病预后意义的研究中，大多数这些具有小单克隆成分的受试者未被发现。这些发现表明有必要修订当前关于偶然发现的单克隆成分的生物学和临床意义的概念。
