台湾沿海植物基隆泽兰中的细胞毒性倍半萜内酯。

Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan.

作者信息

Shen Ya-Ching, Lo Kuang-Liang, Kuo Yao Haur, Khalil Ashraf Taha

机构信息

Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.

出版信息

J Nat Prod. 2005 May;68(5):745-50. doi: 10.1021/np040214k.

DOI:10.1021/np040214k

PMID:15921421

Abstract

Phytochemical investigation of Eupatorium kiirunense has resulted in the isolation of eight new sesquiterpene lactones, constituted by five germacranolides, eupakirunsins A-E (1-5), and three heliangolides, eupaheliangolide A (6), 15-acetoxyheliangin (7), and 3-epi-heliangin (8), in addition to the known heliangin (9) and 8,10-epoxy-9-acetoxythymol angelate (10). The structures of the new compounds were established through detailed analysis of their spectroscopic data. Compounds 6, 8, and 9 exhibited cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells.

摘要

对基隆泽兰（Eupatorium kiirunense）进行植物化学研究，已分离出8种新的倍半萜内酯，其中包括5种吉马烷型内酯，即基隆泽兰素A-E（1-5），以及3种泽兰内酯，即泽兰内酯A（6）、15-乙酰氧基泽兰素（7）和3-表-泽兰素（8），此外还分离出已知的泽兰素（9）和8,10-环氧-9-乙酰氧基百里香酸当归酯（10）。通过对其光谱数据的详细分析确定了新化合物的结构。化合物6、8和9对人口腔表皮样（KB）、宫颈上皮样（Hela）和肝癌（hepa59T/VGH）细胞具有细胞毒性。