CB1受体的基因缺失改善非联想学习。

Genetic deletion of CB1 receptors improves non-associative learning.

作者信息

Degroot Aldemar, Salhoff Craig, Davis Richard J, Nomikos George G

机构信息

Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285-0510, USA.

出版信息

Behav Brain Res. 2005 Jul 1;162(1):161-4. doi: 10.1016/j.bbr.2005.02.018. Epub 2005 Mar 17.

DOI:10.1016/j.bbr.2005.02.018

PMID:15922076

Abstract

Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 and M2/M4, but not M4, receptor knockout mice appeared to have an impaired ability to habituate, whereas CB1 receptor knockout mice showed enhanced habituation compared to wild-type animals. We conclude that CB1 receptor gene invalidation improves habituation tentatively through an increase in cholinergic neurotransmission.

摘要

通过评估CB1受体基因敲除小鼠新型活动监测器中的运动来测量习惯化（一种非联想学习形式），并与毒蕈碱M2、M4以及双M2/M4受体基因敲除小鼠中测量的习惯化作比较。M2和M2/M4受体基因敲除小鼠（而非M4受体基因敲除小鼠）似乎存在习惯化能力受损的情况，而与野生型动物相比，CB1受体基因敲除小鼠表现出更强的习惯化。我们得出结论，CB1受体基因无效化可能通过增加胆碱能神经传递来改善习惯化。