Lazorchak Adam, Jones Mary Elizabeth, Zhuang Yuan
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Trends Immunol. 2005 Jun;26(6):334-8. doi: 10.1016/j.it.2005.03.011.
Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.
淋巴细胞发育长期以来一直是一种实验范式，揭示了哺乳动物基因调控和细胞分化的基本机制。对淋巴细胞发育过程中E蛋白介导的转录调控的研究为解决这些机制问题提供了一种手段。遗传和生化研究都确定了淋巴细胞发育过程中许多由E蛋白介导的重要调控事件。E2A基因是哺乳动物中已知的三种E蛋白基因之一，在B淋巴细胞发育中具有特别重要的作用。近年来，在了解E2A在B淋巴细胞发育过程中的生理靶点方面取得了重大进展。最值得注意的是，在E2A在控制谱系定向和V(D)J重组中的作用方面有了新的见解。本综述主要关注B淋巴细胞发育过程中E2A介导的基因调控。
