[A study on pathogenesis of gastric mucosal lesions in hemodialysis patients, with special reference to the gastric mucosal blood flow].

Clinical characteristics of gastric mucosal lesions in hemodialysis patients were studied. The relationships between the occurrence of gastric mucosal lesions and changes of gastric mucosal blood flow were studied in normal subjects and hemodialysis patients to clarify causes of gastric mucosal lesions in them. Erosive gastritis, gastric ulcers and hemorrhagic gastritis were the main manifestations of the lesions in hemodialysis patients. The lesions were mainly localized in the gastric antrum. Hemorrhagic gastritis lesions were also found in the gastric body as well as in the gastric antrum. The gastric mucosal blood flow in the gastric body showed lower values than in healthy controls while gastric mucosal blood flow in the antrum revealed no such significant difference. Therefore, it can be considered that the low value of gastric mucosal blood flow in the gastric body may contribute to the occurrence of gastric mucosal lesions in the gastric body in hemodialysis patients. However, gastric mucosal lesions in hemodialysis patients were localized mainly in the gastric antrum, and, accordingly, the changes in the gastric mucosal blood flow are not supposed to account for the lesions in the gastric antrum. Further studies are, therefore, required to clarify the causes of gastric mucosal lesions in hemodialysis patients.