Hansmann M L, Kikuchi M, Wacker H H, Radzun H J, Nathwani B N, Hesse K, Parwaresch M R
Department of Pathology, University of Kiel, Germany.
Hum Pathol. 1992 Jun;23(6):676-80. doi: 10.1016/0046-8177(92)90324-v.
The new monoclonal antibody Ki-M1P, which detects a formalin-resistant epitope on conventional paraffin sections, was applied in 20 cases of different stages of Kikuchi-Fujimoto disease. This new pan-macrophage immunoreagent detects plasmacytoid T cells, referred to as plasmacytoid cells, and renders a reliable delineation of these cells against other similar cell types, such as blasts of high-grade B- and T-cell lymphoma. Histiocytes as well as macrophages were strongly positive, and plasmacytoid cells showed a somewhat weaker and primarily granular, intracytoplasmic immunoreactivity. Plasmacytoid cells, being a diagnostic feature of the Kikuchi-Fujimoto disease, facilitate a clear distinction of this disease entity from large cell or high-grade lymphomas. These results may represent an additional argument favoring the histiocytic origin of plasmacytoid cells. Additionally, they may point to an immunohistochemical tool that facilitates the differential diagnosis between Kikuchi-Fujimoto disease, especially in early stages of the disease, and malignant lymphoma.
新型单克隆抗体Ki-M1P可在传统石蜡切片上检测到抗福尔马林表位，应用于20例不同阶段的菊池-藤本病。这种新型全巨噬细胞免疫试剂可检测浆细胞样T细胞（即浆细胞样细胞），并能可靠地将这些细胞与其他相似细胞类型区分开来，如高级别B细胞和T细胞淋巴瘤的母细胞。组织细胞和巨噬细胞呈强阳性，浆细胞样细胞显示出稍弱且主要为颗粒状的胞浆内免疫反应性。浆细胞样细胞是菊池-藤本病的诊断特征，有助于将该疾病实体与大细胞或高级别淋巴瘤明确区分开来。这些结果可能为支持浆细胞样细胞的组织细胞起源提供额外论据。此外，它们可能指向一种免疫组化工具，有助于菊池-藤本病尤其是疾病早期与恶性淋巴瘤之间的鉴别诊断。
