胶束增敏Ce(IV)-Na2S2O3-诺氟沙星化学发光体系及其应用的研究

A study on the micelle-sensitized Ce(IV)-Na2S2O3-norfloxacin chemiluminescence system and its applications.

作者信息

Xie Zenghong, Liao Sulan, Chen Guonan

机构信息

Department of Chemistry, Fuzhou University, Fuzhou 350002, People's Republic of China.

出版信息

Luminescence. 2005 May-Jun;20(3):220-5. doi: 10.1002/bio.824.

DOI:10.1002/bio.824

PMID:15924328

Abstract

A new chemiluminescence (CL) flow-injection method was developed for the determination of norfloxacin. The method is based on the CL reaction of norfloxacin with sodium thiosulphate and Ce(IV) in sulphuric acid medium sensitized by sodium dodecylsulphate. Under optimum conditions, the CL intensity is proportional to the concentration of the norfloxacin in the range 3.89 x 10(-8)-7.18 x 10(-6) g/mL. The detection limit (3 s/k) was 2.21 x 10(-9) g/mL for norfloxacin. The method has been applied successfully to the determination of norfloxacin in pharmaceutical formulations and human urine. The mechanism for this chemiluminescence system is discussed.

摘要

开发了一种用于测定诺氟沙星的新型化学发光（CL）流动注射法。该方法基于在十二烷基硫酸钠敏化的硫酸介质中，诺氟沙星与硫代硫酸钠和Ce(IV)的CL反应。在最佳条件下，CL强度与诺氟沙星浓度在3.89×10(-8)-7.18×10(-6) g/mL范围内成正比。诺氟沙星的检测限（3s/k）为2.21×10(-9) g/mL。该方法已成功应用于药物制剂和人尿中诺氟沙星的测定。讨论了该化学发光体系的机理。