In(Lu)基因对人红细胞上CDw75抗原表达的影响。
The influence of the In(Lu) gene on expression of CDw75 antigens on human red blood cells.
作者信息
Guy K, Green C
机构信息
Human Genetics Unit, Western General Hospital, Edinburgh, U.K.
出版信息
Immunology. 1992 Apr;75(4):713-6.
The influence of the In(Lu) gene on human red blood cell (RBC) expression of CDw75 antigens was examined. CDw75 antigens were increased in expression on Lu(a-b-) cells of the dominant inhibitor type in comparison with red cells from donors of other Lutheran (Lu) phenotypes. In contrast, CD44 epitopes detected with F10-44-2, A3D8 and BU52 monoclonal antibodies (mAb) were decreased in expression on Lu(a-b-) red cells. Among normal blood donors of the common phenotype Lu(a-b+) there was a wide range of expression of CDw75 antigens on red cells. The results show that CDw75 is a quantitative polymorphism of human red cells and, among antigens influenced by the In(Lu) gene, is unique in being up-regulated in expression.
研究了In(Lu)基因对人类红细胞(RBC) CDw75抗原表达的影响。与其他路德血型(Lu)表型供者的红细胞相比，显性抑制型Lu(a-b-)细胞上CDw75抗原的表达增加。相反，用F10-44-2、A3D8和BU52单克隆抗体(mAb)检测到的CD44表位在Lu(a-b-)红细胞上的表达减少。在常见表型Lu(a-b+)的正常献血者中，红细胞上CDw75抗原的表达范围很广。结果表明，CDw75是人类红细胞的一种数量多态性，在受In(Lu)基因影响的抗原中，其表达上调是独特的。
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