B细胞抗原CD75是一种细胞表面唾液酸转移酶。
The B cell antigen CD75 is a cell surface sialytransferase.
作者信息
Stamenkovic I, Asheim H C, Deggerdal A, Blomhoff H K, Smeland E B, Funderud S
机构信息
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
出版信息
J Exp Med. 1990 Aug 1;172(2):641-3. doi: 10.1084/jem.172.2.641.
Abstract
In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialytransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.
摘要
在这项研究中，我们分离出了一个编码B细胞抗原CD75的cDNA克隆。CD75的氨基酸序列显示与人α2,6唾液酸转移酶的序列相同，据信该酶主要与高尔基体复合体相关。这是唾液酸转移酶在细胞表面表达的首次证明，在B细胞中，它可能在细胞间黏附和抗原呈递过程中发挥重要作用。
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