Ishimitsu T, Uehara Y, Numabe A, Tsukada H, Ogawa Y, Iwai J, Ikeda T, Matsuoka H, Sugimoto T, Yagi S
Department of Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Hypertension. 1992 Jun;19(6 Pt 2):804-8. doi: 10.1161/01.hyp.19.6.804.
Evidence has been provided that the immunological mechanism is involved in the genesis or maintenance of hypertension. In the present study, we investigated the effects of interferon gamma, a potent immunomodulator derived from lymphocytes, on hypertension and organ damage in Dahl salt-sensitive rats and in spontaneously hypertensive rats. Subcutaneous injection of interferon gamma (5 x 10(4) units/kg body wt once a week for 10 weeks) reduced blood pressure in Dahl salt-sensitive rats fed a 4% high salt diet (174 versus 194 mm Hg, p less than 0.025). This blood pressure reduction was associated with an improvement of renal functions, an increase in glomerular filtration rate (690 versus 569 ml/day/100 g body wt, p less than 0.05), and decreases in urinary protein excretion (48 versus 78 mg/day/100 g body wt, p less than 0.025) and urinary N-acetyl-beta-D-glucosaminidase excretion (143 versus 183 milliunits/day/100 g body wt, p less than 0.05). Morphological investigation showed a marked resolution of the vascular injuries seen in untreated Dahl salt-sensitive rats, e.g., intimal and medial hyperplasia, with infiltration of inflammatory cells, and significant amelioration of the glomerular sclerotic changes. In contrast, interferon gamma affected neither blood pressure nor renal functions in spontaneously hypertensive rats. These data indicate that interferon gamma ameliorates the development of hypertension and vascular and renal injuries in Dahl salt-sensitive rats. The resolution of vascular and renal injuries contributes, in part, to the antihypertensive action of interferon gamma.
已有证据表明免疫机制参与高血压的发生或维持。在本研究中，我们研究了γ干扰素（一种源自淋巴细胞的强效免疫调节剂）对Dahl盐敏感大鼠和自发性高血压大鼠的高血压及器官损伤的影响。皮下注射γ干扰素（5×10⁴单位/千克体重，每周一次，共10周）可降低喂食4%高盐饮食的Dahl盐敏感大鼠的血压（174对194毫米汞柱，p<0.025）。这种血压降低与肾功能改善、肾小球滤过率增加（690对569毫升/天/100克体重，p<0.05）以及尿蛋白排泄减少（48对78毫克/天/100克体重，p<0.025）和尿N-乙酰-β-D-氨基葡萄糖苷酶排泄减少（143对183毫单位/天/100克体重，p<0.05）有关。形态学研究显示，未治疗的Dahl盐敏感大鼠中所见的血管损伤明显消退，例如内膜和中膜增生、炎症细胞浸润，以及肾小球硬化改变显著改善。相比之下，γ干扰素对自发性高血压大鼠的血压和肾功能均无影响。这些数据表明，γ干扰素可改善Dahl盐敏感大鼠的高血压发展以及血管和肾脏损伤。血管和肾脏损伤的消退部分促成了γ干扰素的降压作用。
