Radi Z A, Miller D L
Veterinary Diagnostic and Investigational Laboratory, College of Veterinary Medicine, The University of Georgia, P.O. Box 1389, Tifton, GA 31794, USA.
Res Vet Sci. 2005 Oct;79(2):125-9. doi: 10.1016/j.rvsc.2004.11.016. Epub 2005 Feb 5.
Calretinin is a calcium-binding protein expressed abundantly in the central and peripheral neural tissues. It has been demonstrated to be a valuable marker in human testicular neoplasia. The immunohistochemical expression of calretinin has been studied in 102 samples of normal (n=25) and three different neoplastic canine testicular tumours (n=77). In normal canine testis, calretinin expression was restricted to Leydig and Sertoli cells of the testis. In tumour tissues, calretinin expression was detected in all tumours investigated (interstitial cell tumours, seminoma, and Sertoli cell tumours), with a cytoplasmic and nuclear pattern of cellular distribution. The present work reports, for the first time, calretinin immunohistochemical expression in normal and neoplastic canine testis.
钙视网膜蛋白是一种在中枢和外周神经组织中大量表达的钙结合蛋白。它已被证明是人类睾丸肿瘤中的一种有价值的标志物。对102份正常（n = 25）和三种不同的犬睾丸肿瘤（n = 77）样本进行了钙视网膜蛋白的免疫组化表达研究。在正常犬睾丸中，钙视网膜蛋白表达局限于睾丸的间质细胞和支持细胞。在肿瘤组织中，在所研究的所有肿瘤（间质细胞瘤、精原细胞瘤和支持细胞瘤）中均检测到钙视网膜蛋白表达，其细胞分布呈细胞质和细胞核模式。本研究首次报道了钙视网膜蛋白在正常和肿瘤性犬睾丸中的免疫组化表达。
