[一名11岁女孩口服磺脲类降糖药相关的低血糖症]
[Hypoglycemia associated with oral sulfonylurea hypoglycaemic agents in an 11-year-old girl].
作者信息
Ramos E, Baron S, Sentanac S, Touati G, Picherot G
机构信息
Service de pédiatrie, hôpital de la mère et de l'enfant, quai Moncousu, Nantes, France.
出版信息
Arch Pediatr. 2005 Jul;12(7):1109-11. doi: 10.1016/j.arcped.2005.03.047.
UNLABELLED
In children more than 8 years old, hyperinsulinism is the most common cause of hypoglycemia.
CASE REPORT
We report the case of an 11-year-old girl who presented recurrent hypoglycemia with endogenous hyperinsulinism (high insulin and C-peptide concentrations). The morphological investigations didn't find insulinoma. Finally the questioning identifies the voluntary intoxication with hypoglycemic agent. At a later date, the sulfonylurea dosage during an hypoglycaemic episode was positive.
CONCLUSION
The sulfonylurea drugs can mimic an endogenous hyperinsulinism and mislead the diagnostic to an insulinoma suspicion and lead to a surgical exploration. A sulfonylurea dosage should be done before planning out surgery.
未标注
在8岁以上儿童中，高胰岛素血症是低血糖最常见的原因。
病例报告
我们报告一例11岁女孩，出现反复低血糖伴内源性高胰岛素血症（胰岛素和C肽浓度升高）。形态学检查未发现胰岛素瘤。最终通过询问确定为服用降糖药导致的故意中毒。之后，低血糖发作时磺脲类药物检测呈阳性。
结论
磺脲类药物可模拟内源性高胰岛素血症，误导诊断为疑似胰岛素瘤并导致手术探查。在计划手术前应进行磺脲类药物检测。
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