Vacca Carmine, Fallarino Francesca, Perruccio Katia, Orabona Ciriana, Bianchi Roberta, Gizzi Stefania, Velardi Andrea, Fioretti Maria Cristina, Puccetti Paolo, Grohmann Ursula
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Microbes Infect. 2005 Jun;7(7-8):1040-8. doi: 10.1016/j.micinf.2005.03.030.
The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.
