Don Manuel, Kwong Betty, Tanaka Chiemi, Brackmann Derald, Nelson Ralph
Department of Electrophysiology, House Ear Institute, Los Angeles, Calif. 90057, USA.
Audiol Neurootol. 2005 Sep-Oct;10(5):274-90. doi: 10.1159/000086001. Epub 2005 May 26.
The failure of standard ABR measures to detect small (< or =1 cm) acoustic tumors has led to the use of enhanced magnetic resonance imaging (MRI) as the standard to screen for small tumors. This study investigates the suitability of the stacked ABR as a sensitive screening alternative to MRI for small acoustic tumors (SATs). The objective of the study was to determine the sensitivity and specificity of the stacked ABR technique for detecting SATs. A total of 54 patients with acoustic tumors identified by MRI that were either < or =1 cm in size or undetected by standard ABR methods, irrespective of size, were studied. A control population of 78 nontumor normal-hearing subjects was also tested. For comparison, two standard ABR measures (IT5 and I-V delay) were also analyzed. The stacked ABR demonstrated 95% sensitivity and 88% specificity; 100% sensitivity was obtained at 50% specificity. Standard ABR measures were much poorer in detecting these tumors. In conclusion, the stacked ABR can be used as a sensitive, widely-available, cost-effective, and comfortable tool for screening SATs.
标准听性脑干反应（ABR）检测小（≤1 cm）听神经瘤失败，导致增强磁共振成像（MRI）被用作筛查小肿瘤的标准方法。本研究探讨叠加ABR作为一种敏感的筛查方法替代MRI用于筛查小听神经瘤（SATs）的适用性。该研究的目的是确定叠加ABR技术检测SATs的敏感性和特异性。共研究了54例经MRI确诊为听神经瘤的患者，这些肿瘤大小≤1 cm或用标准ABR方法未检测到（无论大小）。还测试了78名无肿瘤的正常听力受试者作为对照人群。为作比较，还分析了两种标准ABR指标（IT5和I-V间期）。叠加ABR显示出95%的敏感性和88%的特异性；在特异性为50%时获得了100%的敏感性。标准ABR指标在检测这些肿瘤方面要差得多。总之，叠加ABR可作为一种敏感、广泛可用、经济有效且舒适的工具用于筛查SATs。
