Momm Felix, Bartelt Susanne, Haigis Kristine, Grosse-Sender Astrid, Witucki Gerlo
Department of Radiotherapy, University Hospital Freiburg, Freiburg i. Br., Germany.
Strahlenther Onkol. 2005 Jun;181(6):392-5. doi: 10.1007/s00066-005-1345-3.
It was investigated whether the elementary EORTC/RTOG-CTC score (Common Toxicity Criteria) for radiotherapy skin reactions correlates with spectrophotometric measurements of the skin color. PATIENTS, MATERIAL, AND METHODS: In 41 patients irradiated for unilateral breast cancer the regular scoring by CTC was done during radiotherapy. In parallel, a total of 4,920 spectrophotometric measurements to determine the skin color were performed at baseline, at the beginning of radiotherapy, and at 20, 40 and 60 Gy. The nonirradiated contralateral breast was used for control measurements.
As expected, the skin color (especially red) depended on the radiation dose applied to the skin. The objective spectrophotometric measurements were found to correlate well with the subjective CTC scores.
For classification of acute radiation toxicity there seems to be no need to replace the common CTC scoring by technical methods.
研究欧洲癌症研究与治疗组织/美国放射肿瘤学会基本毒性标准（CTC）中放疗皮肤反应评分与皮肤颜色分光光度测量结果之间是否存在相关性。
患者、材料与方法：41例单侧乳腺癌放疗患者在放疗期间按CTC标准进行常规评分。同时，在基线、放疗开始时、20、40和60 Gy时共进行4920次分光光度测量以确定皮肤颜色。未受照射的对侧乳房用于对照测量。
正如预期，皮肤颜色（尤其是红色）取决于皮肤所接受的辐射剂量。客观的分光光度测量结果与主观的CTC评分具有良好的相关性。
对于急性放射毒性的分级，似乎没有必要用技术方法取代常用的CTC评分。
