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乌干达Chhabra和Codman-Hakim微型精密分流系统1年结果的比较:一项针对195名儿童的前瞻性研究。

Comparison of 1-year outcomes for the Chhabra and Codman-Hakim Micro Precision shunt systems in Uganda: a prospective study in 195 children.

作者信息

Warf Benjamin C

机构信息

CURE Children's Hospital of Uganda, Mbale, Uganda, East Africa.

出版信息

J Neurosurg. 2005 May;102(4 Suppl):358-62. doi: 10.3171/ped.2005.102.4.0358.

DOI:10.3171/ped.2005.102.4.0358
PMID:15926385
Abstract

OBJECT

The author investigated the 1-year outcomes for shunt treatment of hydrocephalic children in Uganda, comparing the results using the inexpensive Chhabra shunt ($35 US dollars), widely used in East Africa, with those using the Codman-Hakim Micro Precision Valve shunt ($650).

METHODS

The results in 195 consecutive children (mostly infants) in whom shunts were placed were studied prospectively. In Group 1, 90 patients randomly received either the Chhabra or Codman shunt as primary treatment for hydrocephalus. In Group 2, 105 patients received the Chhabra shunt when endoscopic third ventriculostomy could not be performed or had failed. The end points of the study were shunt malfunction, shunt migration, wound complication, death, or no problem at 1 year. Of all patients, 9.7% were lost to follow up and 15.9% died before 1 year. The occurrence of complications in all patients were infection (9.7%), migration/disconnection (6.3%), wound complication (5.7%), valve malfunction (3.4%), ventricular catheter obstruction (2.8%), and peritoneal catheter obstruction (1.1%). There was no statistically significant difference in any outcome category for patients receiving the Codman or Chhabra shunt (p = 0.2463-1.0000).

CONCLUSIONS

Ventriculoperitoneal shunt insertion for treatment of hydrocephalus can be performed in a developing country with results similar to those reported in developed countries. No difference in outcome was noted between the two shunt types. No advantage was found in using a shunt system that, in this setting, is prohibitively expensive.

摘要

目的

作者调查了乌干达脑积水儿童分流治疗的1年预后情况,比较了使用在东非广泛应用的廉价Chhabra分流管(35美元)与使用Codman - Hakim微精密瓣膜分流管(650美元)的治疗结果。

方法

对195例连续接受分流管植入的儿童(大多数为婴儿)进行前瞻性研究。在第1组中,90例患者随机接受Chhabra或Codman分流管作为脑积水的主要治疗方法。在第2组中,105例患者在内镜下第三脑室造瘘术无法实施或失败时接受Chhabra分流管。研究的终点是1年时分流管故障、分流管移位、伤口并发症、死亡或无问题。所有患者中,9.7%失访,15.9%在1年前死亡。所有患者并发症的发生率为感染(9.7%)、移位/断开(6.3%)、伤口并发症(5.7%)、瓣膜故障(3.4%)、脑室导管阻塞(2.8%)和腹膜导管阻塞(1.1%)。接受Codman或Chhabra分流管的患者在任何预后类别上均无统计学显著差异(p = 0.2463 - 1.0000)。

结论

在发展中国家可进行脑室腹腔分流术治疗脑积水,其结果与发达国家报道的相似。两种分流管类型在预后方面无差异。在这种情况下,使用昂贵得令人望而却步的分流系统未发现有优势。

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