Zappoli R, Versari A, Paganini M, Arnetoli G, Gangemi P F, Muscas G C, Arneodo M G, Battaglia A
Department of Neurology and Psychiatry, University of Florence, Italy.
Int J Psychophysiol. 1992 Mar;12(2):101-21. doi: 10.1016/0167-8760(92)90002-s.
Bit-color mapped multicomponent CNV complexes and RTs to S2 evoked with a simple warned CNV/RT paradigm were recorded and measured in 20 selected right-handed very healthy volunteers (10 young adults and 10 presenile subjects, mean age 28.3 and 59.6, respectively). EEG and CNV components (post S1, N1, P2, P3; early CNV; N1200; late CNV; CNV resolution) were recorded from Fz, C3, Cz, C4, P3, Pz, and P4 referenced to linked mastoid electrodes. EOG, RT and stimuli were also recorded. The presenile group differed significantly from the younger group in the auditory post-S1 N1 and early (O-wave) and late (P-wave) CNV complex components. A progressive amplitude reduction limited to frontal leads between O-wave and P-wave, the lowest point being reached in the P-wave, was characteristic in the presenile group. Moreover, presenile subjects showed relatively flat CNV waveshapes of low amplitude and, on the whole, performed a little less well than young ones. This finding suggests that the statistically significant changes in auditory post-S1 N1 and CNV activity recorded in our presenile subjects, without any appreciable deficits in behavioral or mental performance, could be alerting signs of early brain involutional processes related to minimal and subclinical decline in orienting, attentiveness and response preparation capabilities. If such is the case, and it could be confirmed in a larger sample of very healthy subjects, these age-related changes in the presenium might prove to be of considerable practical importance for clinical research.
采用简单的预警性CNV/RT范式，对20名选定的右利手非常健康的志愿者（10名年轻人和10名老年前期受试者，平均年龄分别为28.3岁和59.6岁）诱发的双色映射多成分CNV复合体和对S2的反应时进行记录和测量。脑电图和CNV成分（S1后、N1、P2、P3；早期CNV；N1200；晚期CNV；CNV分辨率）从Fz、C3、Cz、C4、P3、Pz和P4记录，参考双侧乳突电极。眼电图、反应时和刺激也进行记录。老年前期组在听觉S1后N1以及早期（O波）和晚期（P波）CNV复合成分方面与年轻组有显著差异。老年前期组的特征是在O波和P波之间，仅限于额部导联的幅度逐渐降低，最低点出现在P波。此外，老年前期受试者的CNV波形相对低平且幅度较小，总体表现比年轻人稍差。这一发现表明，在我们的老年前期受试者中记录到的听觉S1后N1和CNV活动的统计学显著变化，在行为或心理表现上没有明显缺陷，可能是与定向、注意力和反应准备能力的轻微和亚临床下降相关的早期脑退化过程的警示信号。如果情况确实如此，并且能够在更大样本的非常健康的受试者中得到证实，那么这些老年前期与年龄相关的变化可能对临床研究具有相当重要的实际意义。
