丰富环境对大鼠大脑中即刻早期基因表达的昼夜影响。

Diurnal effects of enriched environment on immediate early gene expression in the rat brain.

作者信息

Rönnbäck Annica, Dahlqvist Per, Bergström Sven-Anders, Olsson Tommy

机构信息

Department of Public Health and Clinical Medicine, Medicine, Umeå University Hospital, Sweden.

出版信息

Brain Res. 2005 Jun 7;1046(1-2):137-44. doi: 10.1016/j.brainres.2005.03.051.

DOI:10.1016/j.brainres.2005.03.051

PMID:15927552

Abstract

Rodents housed in an enriched environment (EE) show increased neuronal plasticity with enhanced long-term potentiation and memory performance. We report an EE-induced increase in NGFI-A and Krox-20 mRNA expression exclusively during the dark period of the day. In addition, EE-housed rats showed considerable diurnal variation in NGFI-A, Krox-20, and NGFI-B mRNA expression which was absent in single-housed rats. Thus, EE-induced molecular changes are more evident during the dark phase when the rats have higher motor and exploratory activity. This is important to take into account in future studies of molecular mediators of experience-dependent neuronal plasticity.

摘要

饲养在丰富环境（EE）中的啮齿动物表现出神经元可塑性增加，长期增强作用和记忆能力增强。我们报告，仅在一天中的黑暗期，EE会导致NGFI-A和Krox-20 mRNA表达增加。此外，饲养在EE中的大鼠在NGFI-A、Krox-20和NGFI-B mRNA表达上表现出明显的昼夜变化，而单笼饲养的大鼠则没有这种变化。因此，当大鼠具有较高的运动和探索活动时，EE诱导的分子变化在黑暗阶段更为明显。在未来关于经验依赖性神经元可塑性分子介质的研究中，考虑到这一点很重要。