Gadow K D, Nolan E E, Sverd J
Department of Psychiatry and Behavioral Science, SUNY Stony Brook 11794-8790.
J Am Acad Child Adolesc Psychiatry. 1992 May;31(3):462-71. doi: 10.1097/00004583-199205000-00012.
In this study, 11 prepubertal hyperactive boys with tic disorder received placebo and three doses of methylphenidate (0.1, 0.3, and 0.5 mg/kg) for 2 weeks each, under double-blind conditions. Each boy was observed for approximately 20 hours in the school setting (classroom seatwork activities, lunchroom, and playground). Results showed that methylphenidate effectively suppressed hyperactive/disruptive behaviors in the classroom and physical aggression in the lunchroom and on the playground. Methylphenidate also reduced the occurrence of vocal tics in the classroom and the lunchroom. None of the motor tic measures revealed drug effects, but the lowest mean rate of motor tics occurred on the 0.3 mg/kg dose. On an operationally defined minimal effective dose, only one boy experienced motor tic exacerbation.
在本研究中，11名患有抽动障碍的青春期前多动男孩在双盲条件下，接受了安慰剂以及三个剂量的哌甲酯（0.1、0.3和0.5毫克/千克）治疗，每种剂量治疗2周。在学校环境（课堂作业活动、餐厅和操场）中，对每个男孩进行了约20小时的观察。结果显示，哌甲酯有效抑制了课堂上的多动/破坏性行为以及餐厅和操场上的身体攻击行为。哌甲酯还减少了课堂和餐厅中发声抽动的发生。没有一项运动抽动指标显示出药物效果，但运动抽动的最低平均发生率出现在0.3毫克/千克剂量时。在一个根据操作定义的最小有效剂量下，只有一名男孩出现了运动抽动加重的情况。
