Walters Rebecca M, Smith Samantha H E, Hutchinson M John, Dolan A Mark, Fraser Robert D, Moore Robert J
The Adelaide Centre for Spinal Research, Institute of Medical and Veterinary Science, Department of Pathology, The University of Adelaide, Australia.
Spine (Phila Pa 1976). 2005 Jun 1;30(11):1252-7. doi: 10.1097/01.brs.0000164102.31726.0a.
A prospective in vivo animal study.
To determine whether infection in the juvenile spine influences spinal development.
Discitis is thought to occur in children when blood-borne infection penetrates the highly vascular immature disc. The condition generally resolves without apparent complication, but little is known about the long-term effects on the growing spine.
Twenty-nine 6-week-old lambs underwent discography at multiple lumbar levels using radiographic contrast deliberately inoculated with Staphylococcus epidermidis. No antibiotics were given. Plain radiographs were taken at intervals up to 52 weeks after inoculation for morphometric analysis of the vertebral bodies and discs, and the lumbar spines were prepared for histology.
Sixteen of 44 inoculated discs showed radiological evidence of discitis between 2 and 6 weeks after inoculation. Disc height and disc area were significantly reduced from 2 weeks, and did not recover during the study period. Vertebral body dimensions and overall lumbar spine length were not significantly affected.
Infection of juvenile ovine discs impedes disc development but has no significant effect on vertebral body growth.
一项前瞻性体内动物研究。
确定幼年脊柱感染是否会影响脊柱发育。
人们认为，当血源性感染穿透血管丰富的未成熟椎间盘时，儿童会发生椎间盘炎。这种情况通常可自行缓解，无明显并发症，但对于其对生长中的脊柱的长期影响知之甚少。
29只6周龄羔羊在多个腰椎水平进行椎间盘造影术，使用故意接种表皮葡萄球菌的放射造影剂。未给予抗生素。接种后每隔一段时间拍摄X线平片直至52周后用于椎体和椎间盘的形态计量分析，并对腰椎进行组织学处理。
44个接种椎间盘中有16个在接种后2至6周出现椎间盘炎影像学证据。椎间盘高度和面积从2周起显著降低，并在研究期间未恢复正常；椎体尺寸及整个腰椎长度未受显著影响。
幼年绵羊椎间盘感染会阻碍椎间盘发育，但对椎体生长无显著影响
