Kast Richard E, Altschuler Erick L
University of Vermont,Burlington,VT 05401,USA.
Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):143-7.
Crohn's disease and B cell chronic lymphocytic leukemia (CLL) share a common link in their pathologic mechanisms. Lymphocytes in both diseases fail to undergo apoptosis and die properly. That failure is partly due to increased signaling by tumor necrosis factor (TNF)-alpha, and their respective pathologies directly follow from this apoptosis failure. Bupropion is a commonly used generic antidepressant in clinical use for over a decade, and early evidence indicates it lowers TNF levels. This paper suggests the use of bupropion in CLL to lower TNF levels, which may thereby slow CLL disease course.
克罗恩病和B细胞慢性淋巴细胞白血病（CLL）在病理机制上有共同联系。这两种疾病中的淋巴细胞都无法正常经历凋亡并死亡。这种缺陷部分归因于肿瘤坏死因子（TNF）-α信号增加，并且它们各自的病理状况直接源于这种凋亡缺陷。安非他酮是一种已临床使用十多年的常用非专利抗抑郁药，早期证据表明它能降低TNF水平。本文建议在CLL中使用安非他酮来降低TNF水平，从而可能减缓CLL病程。
