Sanclimens Glòria, Shen Hong, Giralt Ernest, Albericio Fernando, Saltzman Mark William, Royo Miriam
Barcelona Biomedical Research Institute, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028 Barcelona, Spain.
Biopolymers. 2005;80(6):800-14. doi: 10.1002/bip.20301.
A small library of defined peptide dendrimers based on polyproline sequences was designed to demonstrate the feasibility of generating a new type of polymeric agent for therapeutic use. Structural modifications to dendrimer surfaces further enriched the diversity of the library. Data show that the prolinerich dendrimers can be internalized in human epithelial (HeLa) cells, demonstrating the importance of the dendrimeric motif. The promising results described herein suggest that controlled modification of the dendrimer surface should eventually yield proline dendrimers with therapeutic potential.
设计了一个基于聚脯氨酸序列的特定肽树枝状大分子小型文库，以证明生成一种新型治疗用聚合物试剂的可行性。对树枝状大分子表面的结构修饰进一步丰富了文库的多样性。数据表明，富含脯氨酸的树枝状大分子可被人上皮（HeLa）细胞内化，证明了树枝状基序的重要性。本文所述的有前景的结果表明，对树枝状大分子表面的可控修饰最终应能产生具有治疗潜力的脯氨酸树枝状大分子。
