Schwarz-Sommer Z, Gierl A, Berndtgen R, Saedler H
Max-Planck-Institut für Züchtungsforschung, 5000 Köln 30, FRG.
EMBO J. 1985 Oct;4(10):2439-43. doi: 10.1002/j.1460-2075.1985.tb03953.x.
Two states of the a1-m1 allele featuring different phenotypes in the absence as well as in the presence of Spm or En have been cloned and sequenced.. The insertion site and orientation of the Inhibitor (I) element within the two alleles is identical. The sizes of the I elements differ, being 2.2 kb in state 6078 and 789 bp in state 5719A-1. The internal deletion in state 5719A-1 affects sequences within one side of the terminal inverted repeats of the I element. This alteration can be correlated with the decreased response of this state to the Mutator function of Spm. A model for the interaction between Spm (En)-encoded functions and the receptor element is discussed explaining the phenotypic differences between the states of the locus.
已克隆并测序了a1-m1等位基因的两种状态，它们在有无Spm或En的情况下均表现出不同的表型。两个等位基因中抑制因子（I）元件的插入位点和方向是相同的。I元件的大小不同，在状态6078中为2.2 kb，在状态5719A-1中为789 bp。状态5719A-1中的内部缺失影响I元件末端反向重复序列一侧的序列。这种改变可能与该状态对Spm的突变功能反应降低有关。讨论了Spm（En）编码功能与受体元件之间相互作用的模型，解释了该位点不同状态之间的表型差异。
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